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Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms
Joseph M. Collins, Rong Lu, Xinwen Wang, Hao-Jie Zhu and Danxin Wang

Drug Metabolism and Disposition January 2022, 50 (1) 43-48; DOI: https://doi.org/10.1124/dmd.121.000649
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Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey

Drug Metabolism and Disposition January 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644
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Regulation of transporters by perfluorinated carboxylic acids in HepaRG cells
Joe Jongpyo Lim, Youjun Suh, Elaine M Faustman and Julia Yue Cui

Drug Metabolism and Disposition December 14, 2021, DMD-AR-2021-000477; DOI: https://doi.org/10.1124/dmd.121.000477
Open Access
Inhibition of UDP-Glucuronosyltransferase Enzymes by Major Cannabinoids and Their Metabolites
Shamema Nasrin, Christy J. W. Watson, Keti Bardhi, Gabriela Fort, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition December 2021, 49 (12) 1081-1089; DOI: https://doi.org/10.1124/dmd.121.000530
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Complex Cytochrome P450 Kinetics Due to Multisubstrate Binding and Sequential Metabolism. Part 1. Theoretical Considerations
Zeyuan Wang, Erickson M. Paragas, Swati Nagar and Ken Korzekwa

Drug Metabolism and Disposition December 2021, 49 (12) 1090-1099; DOI: https://doi.org/10.1124/dmd.121.000553
Open Access
Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions
Shamema Nasrin, Christy J.W. Watson, Yadira X Perez-Paramo and Philip Lazarus

Drug Metabolism and Disposition December 2021, 49 (12) 1070-1080; DOI: https://doi.org/10.1124/dmd.121.000442
Open Access
Pharmacokinetics and ADME Characterization of Intravenous and Oral [¹⁴C]-Linerixibat in Healthy Male Volunteers
Maciej J. Zamek-Gliszczynski, David Kenworthy, David A. Bershas, Mitesh Sanghvi, Adrian I. Pereira, Jennypher Mudunuru, Lee Crossman, Jill L. Pirhalla, Karl M. Thorpe, Jeremy M.T.J. Dennison, Megan M. McLaughlin, Matthew Allinder, Brandon Swift, Robin L. O’Connor-Semmes and Graeme C. Young

Drug Metabolism and Disposition December 2021, 49 (12) 1109-1117; DOI: https://doi.org/10.1124/dmd.121.000595
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Complex Cytochrome P450 Kinetics Due to Multisubstrate Binding and Sequential Metabolism. Part 2. Modeling of Experimental Data
Erickson M. Paragas, Zeyuan Wang, Ken Korzekwa and Swati Nagar

Drug Metabolism and Disposition December 2021, 49 (12) 1100-1108; DOI: https://doi.org/10.1124/dmd.121.000554
Open Access
Characterization of Cytosolic Glutathione S-Transferases Involved in the Metabolism of the Aromatase Inhibitor, Exemestane
Irina Teslenko, Christy J.W. Watson, Zuping Xia, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition December 2021, 49 (12) 1047-1055; DOI: https://doi.org/10.1124/dmd.121.000635
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Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition
Jennifer Tang, Hong Shen, Xiaofeng Zhao, Vinay K. Holenarsipur, T. Thanga Mariappan, Yueping Zhang, Erika Panfen, Jim Zheng, W. Griffith Humphreys and Yurong Lai

Drug Metabolism and Disposition December 2021, 49 (12) 1063-1069; DOI: https://doi.org/10.1124/dmd.121.000486

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