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Predictive Performance of Physiologically Based Pharmacokinetic Modelling of Beta-Lactam Antibiotic Concentrations in Adipose, Bone and Muscle Tissues
Pieter-Jan De Sutter, Pieter De Cock, Trevor N. Johnson, Helen Musther, Elke Gasthuys and An Vermeulen

Drug Metabolism and Disposition January 13, 2023, DMD-AR-2022-001129; DOI: https://doi.org/10.1124/dmd.122.001129
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Achieving a deeper understanding of drug metabolism and responses using single cell technologies
Abigail M. Wheeler, Colten D. Eberhard, Eric P. Mosher, Yuting Yuan, Hannah N. Wilkins, Herana Kamal Seneviratne, Benjamin C. Orsburn and Namandje N. Bumpus

Drug Metabolism and Disposition January 10, 2023, DMD-MR-2022-001043; DOI: https://doi.org/10.1124/dmd.122.001043
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Correction to “Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver”
Drug Metabolism and Disposition January 2023, 51 (1) 154; DOI: https://doi.org/10.1124/dmd.122.001041err
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Biotransformation of efavirenz and proteomic analysis of P450s and UGTs in mouse, macaque, and human brain-derived in vitro systems
Abigail M. Wheeler, Benjamin C. Orsburn and Namandje N. Bumpus

Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001195; DOI: https://doi.org/10.1124/dmd.122.001195
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Antibiotics-induced depletion of rat microbiota induces changes in the expression of host drug-processing genes and pharmacokinetic behaviors of CYPs probe drugs
Haijun Yang, Yanjuan Zhang, Rong Zhou, Tianyuan Wu, Peng Zhu, Yujie Liu, Jian Zhou, Yalan Xiong, Yanling Xiong, Honghao Zhou, Wei Zhang, Yan Shu, Xiong Li and Qing Li

Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001173; DOI: https://doi.org/10.1124/dmd.122.001173
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CYP3A4 and CYP3A5 expression is regulated by CYP3A4*1G in CRISPR/Cas9 edited HepG2 cells
Weihong Yang, Huan Zhao, Yaojie Dou, Pei Wang, Qi Chang, Xiaomeng Qiao, Xiaofei Wang, Chen Xu, Zhe Zhang and Lirong Zhang

Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001111; DOI: https://doi.org/10.1124/dmd.122.001111
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Absorption, Metabolism, and Excretion of Taselisib (GDC-0032), a Potent β-sparing PI3K Inhibitor, in Rats, Dogs, and Humans
Shuguang Ma, Sungjoon Cho, Srikumar Sahasranaman, Weiping Zhao, Jodie Pang, Xiao Ding, Brian Dean, Bin Wang, Jerry Y Hsu, Joseph Ware and Laurent Salphati

Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001096; DOI: https://doi.org/10.1124/dmd.122.001096
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The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroaki Kato, Hiroshi Yamazaki and Hiroshi Suemizu

Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001102; DOI: https://doi.org/10.1124/dmd.122.001102
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Process and System Clearances in Pharmacokinetic Models: Our Basic Clearance Concepts are Correct
Ken Korzekwa and Swati Nagar

Drug Metabolism and Disposition January 9, 2023, DMD-MR-2022-001060; DOI: https://doi.org/10.1124/dmd.122.001060
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Relevance of Human Aldoketoreductases and Microbial β-Glucuronidases in Testosterone Disposition
Abdul Basit, John K. Amory, Vijaya Saradhi Mettu, Cindy Yanfei Li, Scott Heyward, Parth B. Jariwala, Matthew R. Redinbo and Bhagwat Prasad

Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-000975; DOI: https://doi.org/10.1124/dmd.122.000975

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