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Cytochrome P450–Catalyzed Metabolism of Cannabidiol to the Active Metabolite 7-Hydroxy-Cannabidiol
Jessica L. Beers, Dong Fu and Klarissa D. Jackson

Drug Metabolism and Disposition October 2021, 49 (10) 882-891; DOI: https://doi.org/10.1124/dmd.120.000350
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Prediction of Pregnancy-Induced Changes in Secretory and Total Renal Clearance of Drugs Transported by Organic Anion Transporters
Jinfu Peng, Mayur K. Ladumor and Jashvant D. Unadkat

Drug Metabolism and Disposition October 2021, 49 (10) 929-937; DOI: https://doi.org/10.1124/dmd.121.000557
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Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant Isocitrate Dehydrogenase 1 for Treatment of Isocitrate Dehydrogenase 1-Mutant Malignancies
Yue Chen, Nelamangala V. Nagaraja, Bin Fan, Luke Utley, Rene M. Lemieux, Janeta Popovici-Muller, Lenny Dang, Hyeryun Kim, Liping Yan, Shin-San M. Su, Scott A. Biller and Hua Yang

Drug Metabolism and Disposition October 2021, 49 (10) 870-881; DOI: https://doi.org/10.1124/dmd.120.000234
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Icotinib Induces Mechanism-Based Inactivation of Recombinant Human CYP3A4/5 Possibly via Heme Destruction by Ketene Intermediate
Chen Sun, Huimin Zhao, Wei Li, Yudi Jia, Yi Yang, Ying Peng and Jiang Zheng

Drug Metabolism and Disposition October 2021, 49 (10) 892-901; DOI: https://doi.org/10.1124/dmd.121.000369
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Tetrahydrocannabinol and Its Major Metabolites Are Not (or Are Poor) Substrates or Inhibitors of Human P-Glycoprotein [ATP-Binding Cassette (ABC) B1] and Breast Cancer Resistance Protein (ABCG2)
Xin Chen, Jashvant D. Unadkat and Qingcheng Mao

Drug Metabolism and Disposition October 2021, 49 (10) 910-918; DOI: https://doi.org/10.1124/dmd.121.000505
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Cytochrome b₅ Binds Tightly to Several Human Cytochrome P450 Enzymes
Donghak Kim, Vitchan Kim, Yasuhiro Tateishi and F. Peter Guengerich

Drug Metabolism and Disposition October 2021, 49 (10) 902-909; DOI: https://doi.org/10.1124/dmd.121.000475
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Cytochrome P450 Binding and Bioactivation of Tumor-targeted Duocarmycin Agents
Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott

Drug Metabolism and Disposition October 4, 2021, DMD-AR-2021-000642; DOI: https://doi.org/10.1124/dmd.121.000642
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Endogenous plasma kynurenic acid in human: a newly discovered biomarker for drug-drug interactions involving in OAT1 and OAT3 inhibition
Jennifer Tang, Hong Shen, Xiaofeng Zhao, Vinay K. Holenarsipur, T. Thanga Mariappan, Yueping Zhang, Erika Panfen, Jim Zheng, W. Griffith Humphreys and Yurong Lai

Drug Metabolism and Disposition October 1, 2021, DMD-AR-2021-000486; DOI: https://doi.org/10.1124/dmd.121.000486
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Characterization of cytosolic glutathione-S- transferases (GSTs) involved in the metabolism of the aromatase inhibitor, Exemestane
Irina Teslenko, Christy J.W. Watson, Zuping Xia, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition September 30, 2021, DMD-AR-2021-000635; DOI: https://doi.org/10.1124/dmd.121.000635
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Correction to “In Vivo-to-in Vitro Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach”
Drug Metabolism and Disposition September 2021, 49 (9) 869; DOI: https://doi.org/10.1124/dmd.121.000367err

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