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Pregnane X Receptor and the Gut-Liver Axis: A Recent Update
Moumita Dutta, Joe Jongpyo Lim and Julia Yue Cui

Drug Metabolism and Disposition April 2022, 50 (4) 478-491; DOI: https://doi.org/10.1124/dmd.121.000415
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Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide a Useful Improvement in In Vitro-In Vivo Extrapolation Predictability?
Tsubasa Kameyama, Jasleen K. Sodhi and Leslie Z. Benet

Drug Metabolism and Disposition April 2022, 50 (4) 401-412; DOI: https://doi.org/10.1124/dmd.121.000677
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Linezolid Metabolism Is Catalyzed by Cytochrome P450 2J2, 4F2, and 1B1
R. Scott Obach

Drug Metabolism and Disposition April 2022, 50 (4) 413-421; DOI: https://doi.org/10.1124/dmd.121.000776
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Prediction of Maternal and Fetoplacental Concentrations of Cefazolin, Cefuroxime, and Amoxicillin during Pregnancy Using Bottom-Up Physiologically Based Pharmacokinetic Models
Khaled Abduljalil, Jia Ning, Amita Pansari, Xian Pan and Masoud Jamei

Drug Metabolism and Disposition April 2022, 50 (4) 386-400; DOI: https://doi.org/10.1124/dmd.121.000711
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Characterizing and Quantifying Extrahepatic Metabolism of (-)-∆⁹-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC
Aditya R. Kumar, Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat

Drug Metabolism and Disposition April 3, 2022, DMD-AR-2022-000868; DOI: https://doi.org/10.1124/dmd.122.000868
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Metabolic Profiling of S-praziquantel: Structure Elucidation Using the Crystalline Sponge Method in Combination with Mass Spectrometry and Nuclear Magnetic Resonance
Lara Rosenberger, Judith Jenniches, Carolina von Essen, Anupam Khutia, Clemens Kühn, Andreas Marx, Katrin Georgi, Anna K. H. Hirsch, Rolf W. Hartmann and Lassina Badolo

Drug Metabolism and Disposition April 2022, 50 (4) 320-326; DOI: https://doi.org/10.1124/dmd.121.000663
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Bilirubin Reduces the Uptake of Estrogen Precursors and the Followed Synthesis of Estradiol in Human Placental Syncytiotrophoblasts via Inhibition and Downregulation of Organic Anion Transporter 4
Yingqiong Zhang, Yujia Chen, Binxin Dai, Mengru Bai, Shuanghui Lu, Nengming Lin, Hui Zhou and Huidi Jiang

Drug Metabolism and Disposition April 2022, 50 (4) 341-350; DOI: https://doi.org/10.1124/dmd.121.000685
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In Vitro and In Vivo Metabolism of a Novel Antimitochondrial Cancer Metabolism Agent, CPI-613, in Rat and Human
Vijay Bhasker Reddy, Lakmal Boteju, Asela Boteju, Li Shen, Kelem Kassahun, Nageshwar Reddy, Adrian Sheldon, Sanjeev Luther and Ke Hu

Drug Metabolism and Disposition April 2022, 50 (4) 361-373; DOI: https://doi.org/10.1124/dmd.121.000726
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Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients
P. Aviles, R. Altares, L. van Andel, R. Lubomirov, S. Fudio, H. Rosing, F. M. Márquez del Pino, M.M. Tibben, G. Benedit, L. Nan-Offeringa, X.E. Luepke Estefan, A. Francesch, A. Zeaiter, C. Cuevas, J.H.M. Schellens and J.H. Beijnen

Drug Metabolism and Disposition April 2022, 50 (4) 327-340; DOI: https://doi.org/10.1124/dmd.121.000668
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Comprehensive Predictions of Cytochrome P450 (P450)-Mediated In Vivo Cannabinoid-Drug Interactions Based on Reversible and Time-Dependent P450 Inhibition in Human Liver Microsomes
Sumit Bansal, Mary F. Paine and Jashvant D. Unadkat

Drug Metabolism and Disposition April 2022, 50 (4) 351-360; DOI: https://doi.org/10.1124/dmd.121.000734

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