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Inhibition of UDP-glucuronosyltransferase enzymes by major cannabinoids and their metabolites
Shamema Nasrin, Christy J.W. Watson, Keti Bardhi, Gabriela Fort, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition September 7, 2021, DMD-AR-2021-000530; DOI: https://doi.org/10.1124/dmd.121.000530
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Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions
Shamema Nasrin, Christy J.W. Watson, Yadira X Perez-Paramo and Philip Lazarus

Drug Metabolism and Disposition September 7, 2021, DMD-AR-2021-000442; DOI: https://doi.org/10.1124/dmd.121.000442
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Messenger RNA Expression of Albumin, Transferrin, Transthyretin, Asialoglycoprotein Receptor, Cytochrome P450 Isoform, Uptake Transporter, and Efflux Transporter Genes as a Function of Culture Duration in Prolonged Cultured Cryopreserved Human Hepatocytes as Collagen-Matrigel Sandwich Cultures: Evidence for Redifferentiation upon Prolonged Culturing
Qian Yang and Albert P. Li

Drug Metabolism and Disposition September 2021, 49 (9) 790-802; DOI: https://doi.org/10.1124/dmd.121.000424
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Impact of Interindividual Differences in Plasma Fraction Unbound on the Pharmacokinetics of a Novel Syk Kinase Inhibitor in Beagle Dogs
Andy Pike, Barry Jones, Roshini Markandu and Daniel O’Neill

Drug Metabolism and Disposition September 2021, 49 (9) 736-742; DOI: https://doi.org/10.1124/dmd.121.000409
Open Access
Comparative Hepatic and Intestinal Efflux Transport of Statins
Feng Deng, Suvi-Kukka Tuomi, Mikko Neuvonen, Päivi Hirvensalo, Sami Kulju, Christoph Wenzel, Stefan Oswald, Anne M. Filppula and Mikko Niemi

Drug Metabolism and Disposition September 2021, 49 (9) 750-759; DOI: https://doi.org/10.1124/dmd.121.000430
Open Access
Evaluation of Normothermic Machine Perfusion of Porcine Livers as a Novel Preclinical Model to Predict Biliary Clearance and Transporter-Mediated Drug-Drug Interactions Using Statins
L. J. Stevens, A. Z. X. Zhu, P. P. Chothe, S. K. Chowdhury, J. M. Donkers, W. H. J. Vaes, C. A. J. Knibbe, I. P. J. Alwayn and E. van de Steeg

Drug Metabolism and Disposition September 2021, 49 (9) 780-789; DOI: https://doi.org/10.1124/dmd.121.000521
Open Access
Contribution of Extrahepatic Aldehyde Oxidase Activity to Human Clearance
Kirk D. Kozminski, Jangir Selimkhanov, Scott Heyward and Michael A. Zientek

Drug Metabolism and Disposition September 2021, 49 (9) 743-749; DOI: https://doi.org/10.1124/dmd.120.000313
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The Inactivation of Human Aldehyde Oxidase 1 by Hydrogen Peroxide and Superoxide
Claudia Garrido and Silke Leimkühler

Drug Metabolism and Disposition September 2021, 49 (9) 729-735; DOI: https://doi.org/10.1124/dmd.121.000549
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Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor κ-B Pathway in Mouse Nonalcoholic Fatty Liver Disease
Ran Zhang, Dan Xu, Yirui Zhang, Rui Wang, Na Yang, Yunge Lou, Haokai Zhao, Jiye Aa, Guangji Wang and Yuan Xie

Drug Metabolism and Disposition September 2021, 49 (9) 770-779; DOI: https://doi.org/10.1124/dmd.121.000438
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Characterization of Hepatic UDP-Glucuronosyltransferase Enzyme Abundance-Activity Correlations and Population Variability Using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes
Ryan H. Takahashi, William F. Forrest, Alexander D. Smith, Justine Badee, NaHong Qiu, Stephan Schmidt, Abby C. Collier, Neil Parrott and Stephen Fowler

Drug Metabolism and Disposition September 2021, 49 (9) 760-769; DOI: https://doi.org/10.1124/dmd.121.000474

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