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Stereoselective Metabolism of Bupropion to Active Metabolites in Cellular Fractions of Human Liver and Intestine
Nadia O Bamfo, Jessica BL Lu and Zeruesenay Desta

Drug Metabolism and Disposition January 2023, 51 (1) 54-66; DOI: https://doi.org/10.1124/dmd.122.000867
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Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective Na_V1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver
Daigo Asano, Koichi Nakamura, Yumi Nishiya, Hideyuki Shiozawa, Hideo Takakusa, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Takakazu Hamada, Chizuko Yahara, Nobuaki Watanabe and Kouichi Yoshinari

Drug Metabolism and Disposition January 2023, 51 (1) 67-80; DOI: https://doi.org/10.1124/dmd.122.001000
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Covalent Binding Mechanism of Furmonertinib and Osimertinib With Human Serum Albumin
Yali Wu, Lili Chen, Jian Chen, Hao Xue, Qingfeng He, Dafang Zhong and Xingxing Diao

Drug Metabolism and Disposition January 2023, 51 (1) 8-16; DOI: https://doi.org/10.1124/dmd.122.001019
Open Access
Cytochrome P450 Transcriptional Regulation by Testis‐Specific Y‐Encoded‐Like Protein: Identification of Novel Upstream Transcription Factors
Suganti Shivaram, Huanyao Gao, Sisi Qin, Duan Liu, Richard M. Weinshilboum and Liewei Wang

Drug Metabolism and Disposition January 2023, 51 (1) 1-7; DOI: https://doi.org/10.1124/dmd.122.000945
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A Comprehensive Investigation of Dog Cytochrome P450 3A (CYP3A) Reveals a Functional Role of Newly Identified CYP3A98 in Small Intestine
Yasuhiro Uno, Shiori Jikuya, Yutaro Noda, Norie Murayama and Hiroshi Yamazaki

Drug Metabolism and Disposition January 2023, 51 (1) 38-45; DOI: https://doi.org/10.1124/dmd.121.000749
Open Access
CYP2C19 Plays a Major Role in the Hepatic N-Oxidation of Cotinine
Yadira X. Perez-Paramo, Christy J.W. Watson, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition January 2023, 51 (1) 29-37; DOI: https://doi.org/10.1124/dmd.121.000624
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Quantitative Evaluation of the Contribution of Each Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoform to Reduction Reactions of Compounds Containing a Ketone Group in the Human Liver
Hiroyuki Ichida, Tatsuki Fukami, Keito Amai, Kohei Suzuki, Kenji Mishiro, Shiori Takano, Wataru Obuchi, Zhengyu Zhang, Akiko Watanabe, Masataka Nakano, Kengo Watanabe and Miki Nakajima

Drug Metabolism and Disposition January 2023, 51 (1) 17-28; DOI: https://doi.org/10.1124/dmd.122.001037
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Significance of basal membrane permeability of epithelial cells in predicting intestinal drug absorption
Aoi Yoshitomo, Satoshi Asano, Shizuka Hozuki, Yuta Tamemoto, Yukihiro Shibata, Natsumi Hashimoto, Keita Takahashi, Yoko Sasaki, Naoka Ozawa, Michiharu Kageyama, Takeshi Iijima, Yasuhiro Kazuki, Hiromi Sato and Akihiro Hisaka

Drug Metabolism and Disposition December 7, 2022, DMD-AR-2022-000907; DOI: https://doi.org/10.1124/dmd.122.000907
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Pharmacokinetic/pharmacodynamic models of an Alzheimer's drug, donepezil, in rats
Akiko Kiriyama, Shunsuke Kimura and Shugo Yamashita

Drug Metabolism and Disposition December 7, 2022, DMD-AR-2022-001061; DOI: https://doi.org/10.1124/dmd.122.001061
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Contribution of UGT enzymes to human drug metabolism stereoselectivity: a case study of medetomidine, RO5263397, propranolol and testosterone
Nicolò Milani, NaHong Qiu and Stephen Fowler

Drug Metabolism and Disposition December 7, 2022, DMD-AR-2022-001024; DOI: https://doi.org/10.1124/dmd.122.001024

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