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Assessing Liver-to-Plasma Partition Coefficients and In Silico Calculation Methods: When Does the Hepatic Model Matter in PBPK?
Xiaonan Li and William J. Jusko

Drug Metabolism and Disposition December 2022, 50 (12) 1501-1512; DOI: https://doi.org/10.1124/dmd.122.000994
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Opportunities for accelerating drug discovery and development by using engineered drug-metabolizing enzymes
Elizabeth M. J. Gillam and Valerie M Kramlinger

Drug Metabolism and Disposition December 2, 2022, DMD-MR-2021-000743; DOI: https://doi.org/10.1124/dmd.121.000743
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Comprehensive analyses of the intracellular and in vivo disposition of Fab-siRNA conjugate to identify key issues to improve its in vivo activity
Asami Toshima, Yasuhisa Shiraishi, Daisuke Shinmi, Yoshiyuki Kagawa and Junichi Enokizono

Drug Metabolism and Disposition December 2, 2022, DMD-AR-2022-001098; DOI: https://doi.org/10.1124/dmd.122.001098
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Quantitative CYP3A4 induction risk assessment using human hepatocytes complemented with pregnane X receptor (PXR)-activating profiles
Aynur Ekiciler, Wen Li Kelly Chen, Yan Bo, Alessandra Pugliano, Massimiliano Donzelli, Neil Parrott and Kenichi Umehara

Drug Metabolism and Disposition December 2, 2022, DMD-AR-2022-001132; DOI: https://doi.org/10.1124/dmd.122.001132
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Intravital microscopy reveals unforeseen biodistribution within the liver and kidney mechanistically connected to the clearance of a bifunctional antibody
Amita Datta-Mannan, Bruce A. Molitoris, Yiqing Feng, Michelle M. Martinez, Ruben M. Sandoval, Robin M Brown, Daniel Merkel, Johnny E. Croy and Kenneth W. Dunn

Drug Metabolism and Disposition December 2, 2022, DMD-AR-2022-001049; DOI: https://doi.org/10.1124/dmd.122.001049
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Cell and tissue specific metabolism of nucleoside and nucleotide drugs: case studies and implications for precision medicine
Elaine E To

Drug Metabolism and Disposition November 29, 2022, DMD-MR-2022-000856; DOI: https://doi.org/10.1124/dmd.122.000856
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Maternal and Fetal Exposure to (-)-Δ⁹-tetrahydrocannabinol and Its Major Metabolites in Pregnant Mice Is Differentially Impacted by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP)
Xin Chen, Jashvant D. Unadkat and Qingcheng Mao

Drug Metabolism and Disposition November 29, 2022, DMD-AR-2022-001110; DOI: https://doi.org/10.1124/dmd.122.001110
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Quantification of accurate composition and total abundance of homologous proteins by conserved-plus-surrogate peptide (CPSP) approach: Quantification of UDP glucuronosyltransferases in human tissues
Deepak Ahire, Mitesh Patel, Sujal V Deshmukh and Bhagwat Prasad

Drug Metabolism and Disposition November 29, 2022, DMD-AR-2022-001155; DOI: https://doi.org/10.1124/dmd.122.001155
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Hydroxychloroquine is metabolized by CYP2D6, CYP3A4, and CYP2C8, and inhibits CYP2D6, while its metabolites also inhibit CYP3A in vitro
Marie-Noëlle Paludetto, Mika Kurkela, Helinä Kahma, Janne T. Backman, Mikko Niemi and Anne M. Filppula

Drug Metabolism and Disposition November 29, 2022, DMD-AR-2022-001018; DOI: https://doi.org/10.1124/dmd.122.001018
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Multidisciplinary Insights into the Structure-Function Relationship of the CYP2B6 Active Site
Ethan D. Angle and Philip M Cox

Drug Metabolism and Disposition November 23, 2022, DMD-MR-2022-000853; DOI: https://doi.org/10.1124/dmd.122.000853

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