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Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver
Sheena Sharma, Deepak Ahire, Abdul Basit, Maria Lajoie, Christina Wang, Min S. Lee, Diana L. Blithe, John K. Amory, Dilip K. Singh, Scott Heyward and Bhagwat Prasad

Drug Metabolism and Disposition December 2022, 50 (12) 1493-1500; DOI: https://doi.org/10.1124/dmd.122.001041
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Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity Toward Tenofovir Diphosphate
Herana Kamal Seneviratne

Drug Metabolism and Disposition November 17, 2022, DMD-AR-2022-000855; DOI: https://doi.org/10.1124/dmd.122.000855
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A physiological-based pharmacokinetic model embedded with a target-mediated drug disposition mechanism can characterize single dose warfarin pharmacokinetic profiles in subjects with various CYP2C9 genotypes under different co-treatments
Shen Cheng, Darcy R Flora, Allan E. Rettie, Richard C. Brundage and Timothy S. Tracy

Drug Metabolism and Disposition November 15, 2022, DMD-AR-2022-001048; DOI: https://doi.org/10.1124/dmd.122.001048
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Activity and Expression of Carboxylesterases and Arylacetamide Deacetylase in Human Ocular Tissues
Anam Hammid, John K. Fallon, Toni Lassila, Paula Vieiro, Anusha Balla, Francisco Gonzalez, Arto Urtti, Philip C. Smith, Ari Tolonen and Paavo Honkakoski

Drug Metabolism and Disposition December 2022, 50 (12) 1483-1492; DOI: https://doi.org/10.1124/dmd.122.000993
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Human Pharmacokinetics of LYS006, an Oral Leukotriene A4 Hydrolase Inhibitor Displaying Target-Mediated Drug Disposition
Birk Poller, David Pearson, Luc Alexis Leuthold, Martin Fink, Astrid Jullion, Patrick Schweigler, Ester Tor Carreras, Cyrille Marvalin, Christian Loesche and H. Markus Weiss

Drug Metabolism and Disposition December 2022, 50 (12) 1472-1482; DOI: https://doi.org/10.1124/dmd.121.000803
Open Access
Identification of 5-Hydroxycotinine in the Plasma of Nicotine-Treated Mice: Implications for Cotinine Metabolism and Disposition in Vivo
Keiko Kanamori, Syed M. Ahmad, Chang Sung Shin, Abdul Hamid and Kabirullah Lutfy

Drug Metabolism and Disposition December 2022, 50 (12) 1454-1463; DOI: https://doi.org/10.1124/dmd.122.001059
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Chronic Treatment With WY-14643 Induces Tumorigenesis and Triglyceride Accumulation in Mouse Livers
Jie Yang, Shicheng Fan, Yifei Zhang, Min Huang, Yue Gao and Huichang Bi

Drug Metabolism and Disposition December 2022, 50 (12) 1464-1471; DOI: https://doi.org/10.1124/dmd.122.000908
Open Access
Investigation of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of the HIV-1 Maturation Inhibitor GSK3640254 Using an Intravenous Microtracer Combined with EnteroTracker for Biliary Sampling
Bo Wen, Ying Zhang, Graeme C. Young, David Kenworthy, Adrian Pereira, Jill Pirhalla, Janine Doyle, Bethany Jordon, Joyce Zhan and Mark Johnson

Drug Metabolism and Disposition November 2022, 50 (11) 1442-1453; DOI: https://doi.org/10.1124/dmd.122.000955
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Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes
Yasuhiro Uno, Norie Murayama, Moe Ijiri, Hiroaki Kawaguchi, Osamu Yamato, Mitsuya Shiraishi, Atsushi Asano, Hiroki Teraoka, Hazuki Mizukawa, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka and Hiroshi Yamazaki

Drug Metabolism and Disposition November 2022, 50 (11) 1434-1441; DOI: https://doi.org/10.1124/dmd.122.000930
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Molecular and Functional Characterization of N-Acetyltransferases in Common Marmosets and Pigs
Yasuhiro Uno, Shotaro Uehara, Moe Ijiri, Hiroaki Kawaguchi, Atsushi Asano, Mitsuya Shiraishi, Kaito Banju, Norie Murayama and Hiroshi Yamazaki

Drug Metabolism and Disposition November 2022, 50 (11) 1429-1433; DOI: https://doi.org/10.1124/dmd.122.000919

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