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Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism
Lydia Wang-Lakshman, Zhuang Miao, Lai Wang, Helen Gu, Mark Kagan, Jessie Gu, Elizabeth McNamara, Markus Walles, Ralph Woessner, Gian Camenisch, Heidi J. Einolf and Jin Chen

Drug Metabolism and Disposition July 2021, 49 (7) 548-562; DOI: https://doi.org/10.1124/dmd.120.000349
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Nonclinical Pharmacokinetics and Absorption, Distribution, Metabolism, and Excretion of Givosiran, the First Approved N-Acetylgalactosamine–Conjugated RNA Interference Therapeutic
Jing Li, Ju Liu, Xuemei Zhang, Valerie Clausen, Chris Tran, Michael Arciprete, Qianfan Wang, Carrie Rocca, Li-Hua Guan, Guodong Zhang, Diana Najarian, Yuanxin Xu, Peter Smith, Jing-Tao Wu and Saeho Chong

Drug Metabolism and Disposition July 2021, 49 (7) 572-580; DOI: https://doi.org/10.1124/dmd.121.000381
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Hepatic Scaling Factors for In Vitro–In Vivo Extrapolation of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis
Areti-Maria Vasilogianni, Brahim Achour, Daniel Scotcher, Sheila Annie Peters, Zubida M. Al-Majdoub, Jill Barber and Amin Rostami-Hodjegan

Drug Metabolism and Disposition July 2021, 49 (7) 563-571; DOI: https://doi.org/10.1124/dmd.121.000359
Open Access
Assessment of the Potential for Veverimer Drug-Drug Interactions
Dawn Parsell, Jun Shao, Robert Guttendorf, Vandana Mathur, Elizabeth Li, Yick Sen Wu, Li Tsao, Scott Tabakman, Yuri Stasiv, Angela Lee, Kalpesh Biyani and Gerrit Klaerner

Drug Metabolism and Disposition July 2021, 49 (7) 490-500; DOI: https://doi.org/10.1124/dmd.121.000366
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Multiple Computational Approaches for Predicting Drug Interactions with Human Equilibrative Nucleoside Transporter 1
Siennah R. Miller, Thomas R. Lane, Kimberley M. Zorn, Sean Ekins, Stephen H. Wright and Nathan J. Cherrington

Drug Metabolism and Disposition July 2021, 49 (7) 479-489; DOI: https://doi.org/10.1124/dmd.121.000423
Open Access
Primary Human Hepatocyte Spheroids as an In Vitro Tool for Investigating Drug Compounds with Low Hepatic Clearance
Julia Riede, Birgit M. Wollmann, Espen Molden and Magnus Ingelman-Sundberg

Drug Metabolism and Disposition July 2021, 49 (7) 501-508; DOI: https://doi.org/10.1124/dmd.120.000340
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Development and Verification of a Linked Δ⁹-THC/11-OH-THC Physiologically Based Pharmacokinetic Model in Healthy, Nonpregnant Population and Extrapolation to Pregnant Women
Gabriela I. Patilea-Vrana and Jashvant D. Unadkat

Drug Metabolism and Disposition July 2021, 49 (7) 509-520; DOI: https://doi.org/10.1124/dmd.120.000322
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Investigating the Utility of Humanized Pregnane X Receptor-Constitutive Androstane Receptor-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction
Justin Q. Ly, Susan Wong, Liling Liu, Ruina Li, Kirsten Messick and Jae H. Chang

Drug Metabolism and Disposition July 2021, 49 (7) 540-547; DOI: https://doi.org/10.1124/dmd.121.000439
Open Access
Preliminary Flow Modeling by Hybrid Automata Alternating Continuous Reaction and Discrete Transit for Pharmacokinetics
Satoshi Koyama

Drug Metabolism and Disposition July 2021, 49 (7) 521-529; DOI: https://doi.org/10.1124/dmd.120.000227
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Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling
Christine M. Bowman, Buyun Chen, Jonathan Cheong, Liling Liu, Yuan Chen and Jialin Mao

Drug Metabolism and Disposition July 2021, 49 (7) 530-539; DOI: https://doi.org/10.1124/dmd.120.000315

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