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In Vitro Metabolism of 2-Methoxy-N-[3-[4-[3-methyl-4-[(6-methyl- 3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide (CP-724,714) by Aldehyde Oxidase and Predicting Its Percent Contribution Relative to CYP-Mediated Metabolism
Kazuko Inoue, Kiyomi Kikuchi, Kazumi Takahashi, Seiji Hitaoka, Kazutomi Kusano and Takafumi Komori

Drug Metabolism and Disposition August 2023, 51 (8) 962-969; DOI: https://doi.org/10.1124/dmd.122.000995
Open Access
How Cryo-EM Has Expanded Our Understanding of Membrane Transporters
Stefanie A. Baril, Tomoka Gose and John D. Schuetz

Drug Metabolism and Disposition August 2023, 51 (8) 904-922; DOI: https://doi.org/10.1124/dmd.122.001004
Open Access
Mass Balance and Absorption, Distribution, Metabolism, and Excretion Properties of Balcinrenone following Oral Administration in Combination with Intravenous Microtracer in Healthy Subjects
Bo Lindmark, Xue-Qing Li, Chandrali Bhattacharya, Greggory Housler, Maria Heijer, Ryan A. Bragg, Malin Gränfors, Marta Pelay-Gimeno, Wouter H.J. Vaes, Somasekhara Menakuru, Patricia Ely Pizzato, Hans Ericsson and Susanne Johansson

Drug Metabolism and Disposition August 2023, 51 (8) 995-1004; DOI: https://doi.org/10.1124/dmd.122.001240
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METTL7A (TMT1A) and METTL7B (TMT1B) Are Responsible for Alkyl S-Thiol Methyl Transferase Activity in Liver
Drake A. Russell, Marvin K. Chau, Yuanyuan Shi, Ian N. Levasseur, Benjamin J. Maldonato and Rheem A. Totah

Drug Metabolism and Disposition August 2023, 51 (8) 1024-1034; DOI: https://doi.org/10.1124/dmd.123.001268
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Soy Protein Containing Diet Attenuates Murine Drug Exposure and Activity via Hepatic and Intestinal Cytochrome P450 Induction
Jill M. Wetter, Rita Ciurlionis, Caitlin J. Krause, Michael J. Liguori, Christian Goess, Suzanne Mathieu and J. Cory Kalvass

Drug Metabolism and Disposition August 2023, 51 (8) 1005-1015; DOI: https://doi.org/10.1124/dmd.123.001249
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Assumptions Underlying Hepatic Clearance Models: Recognizing the Influence of Saturable Protein Binding on Driving Force Concentration and Discrimination Between Models of Hepatic Clearance
Julia A. Schulz Pauly, Jin Wang, Colin J. Phipps and John Cory Kalvass

Drug Metabolism and Disposition August 2023, 51 (8) 1046-1052; DOI: https://doi.org/10.1124/dmd.123.001326
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Representative Rodent Models for Renal Transporter Alterations in Human Nonalcoholic Steatohepatitis
Kayla L. Frost, Joseph L. Jilek, Erica L. Toth, Michael J. Goedken, Stephen H. Wright and Nathan J. Cherrington

Drug Metabolism and Disposition August 2023, 51 (8) 970-981; DOI: https://doi.org/10.1124/dmd.122.001133
Open Access
Systemic Exposure, Metabolism, and Elimination of [¹⁴C]-Labeled Amino Lipid, Lipid 5, after a Single Administration of mRNA Encapsulating Lipid Nanoparticles to Sprague-Dawley Rats
Douglas Burdette, Lei Ci, Barclay Shilliday, Richard Slauter, Andrew Auerbach, Matthew Kenney, Örn Almarsson, Eugene Cheung and Tracy Hendrick

Drug Metabolism and Disposition July 2023, 51 (7) 804-812; DOI: https://doi.org/10.1124/dmd.122.001194
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Variants of Flavin-Containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources
Miaki Makiguchi, Makiko Shimizu, Yuka Yokota, Erika Shimamura, Eiji Hishinuma, Sakae Saito, Masahiro Hiratsuka and Hiroshi Yamazaki

Drug Metabolism and Disposition July 2023, 51 (7) 884-891; DOI: https://doi.org/10.1124/dmd.123.001310
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The Disconnect in Intrinsic Clearance Determined in Human Hepatocytes and Liver Microsomes Results from Divergent Cytochrome P450 Activities
Tashinga E. Bapiro, Scott Martin, Stephen D. Wilkinson, Alexandra L. Orton, Niresh Hariparsad, Stephanie Harlfinger and Dermot F. McGinnity

Drug Metabolism and Disposition July 2023, 51 (7) 892-901; DOI: https://doi.org/10.1124/dmd.123.001323

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