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Drug Metabolism & Disposition

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Latest Articles

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    Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity
    Linlin Sheng, Qi Luo and Ligong Chen
    Drug Metabolism and Disposition February 12, 2022, DMD-AR-2021-000705; DOI: https://doi.org/10.1124/dmd.121.000705
  • You have access
    Characterizing the pharmacokinetics and biodistribution of therapeutic proteins: an industry white paper
    Kathryn Ball, Gerard Bruin, Enrique Escandon, Christoph Funk, Joao NS Pereira, Tong-Yuan Yang and Hongbin Yu
    Drug Metabolism and Disposition February 11, 2022, DMD-MR-2021-000463; DOI: https://doi.org/10.1124/dmd.121.000463
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    Absorption, Distribution, Metabolism, and Excretion (ADME) of Therapeutic Proteins: Current Industry Practices and Future Perspectives
    Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony J Lee, Jennifer A Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu
    Drug Metabolism and Disposition February 11, 2022, DMD-MR-2021-000461; DOI: https://doi.org/10.1124/dmd.121.000461
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    In Defense of Current Concepts and Applications of Clearance in Drug Development and Therapeutics
    Malcolm Rowland, Michael S. Roberts and K. Sandy Pang
    Drug Metabolism and Disposition February 2022, 50 (2) 187-190; DOI: https://doi.org/10.1124/dmd.121.000637
  • Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
    You have access
    Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
    Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li
    Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681
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    The Impact of Age and Genetics on Naltrexone Biotransformation
    Stephani L. Stancil, Whitney Nolte, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder
    Drug Metabolism and Disposition February 2022, 50 (2) 168-173; DOI: https://doi.org/10.1124/dmd.121.000646
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    The in vivo pharmacokinetics of block copolymers containing polyethylene glycol used in nanocarrier drug delivery systems
    Lei Yin, Yiling Pang, Lin Shan and Jingkai Gu
    Drug Metabolism and Disposition January 22, 2022, DMD-MR-2021-000568; DOI: https://doi.org/10.1124/dmd.121.000568
  • The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
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    The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
    Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
    Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640
  • Open Access
    Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
    Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
    Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632
  • Evaluation of ADMET Predictor in Early Discovery Drug Metabolism and Pharmacokinetics Project Work
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    Evaluation of ADMET Predictor in Early Discovery Drug Metabolism and Pharmacokinetics Project Work
    Anna-Karin Sohlenius-Sternbeck and Ylva Terelius
    Drug Metabolism and Disposition February 2022, 50 (2) 95-104; DOI: https://doi.org/10.1124/dmd.121.000552

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