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Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity
Linlin Sheng, Qi Luo and Ligong Chen

Drug Metabolism and Disposition February 12, 2022, DMD-AR-2021-000705; DOI: https://doi.org/10.1124/dmd.121.000705
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Characterizing the pharmacokinetics and biodistribution of therapeutic proteins: an industry white paper
Kathryn Ball, Gerard Bruin, Enrique Escandon, Christoph Funk, Joao NS Pereira, Tong-Yuan Yang and Hongbin Yu

Drug Metabolism and Disposition February 11, 2022, DMD-MR-2021-000463; DOI: https://doi.org/10.1124/dmd.121.000463
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Absorption, Distribution, Metabolism, and Excretion (ADME) of Therapeutic Proteins: Current Industry Practices and Future Perspectives
Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony J Lee, Jennifer A Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu

Drug Metabolism and Disposition February 11, 2022, DMD-MR-2021-000461; DOI: https://doi.org/10.1124/dmd.121.000461
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In Defense of Current Concepts and Applications of Clearance in Drug Development and Therapeutics
Malcolm Rowland, Michael S. Roberts and K. Sandy Pang

Drug Metabolism and Disposition February 2022, 50 (2) 187-190; DOI: https://doi.org/10.1124/dmd.121.000637
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Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li

Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681
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The Impact of Age and Genetics on Naltrexone Biotransformation
Stephani L. Stancil, Whitney Nolte, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder

Drug Metabolism and Disposition February 2022, 50 (2) 168-173; DOI: https://doi.org/10.1124/dmd.121.000646
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The in vivo pharmacokinetics of block copolymers containing polyethylene glycol used in nanocarrier drug delivery systems
Lei Yin, Yiling Pang, Lin Shan and Jingkai Gu

Drug Metabolism and Disposition January 22, 2022, DMD-MR-2021-000568; DOI: https://doi.org/10.1124/dmd.121.000568
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The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy

Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640
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Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon

Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632
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Evaluation of ADMET Predictor in Early Discovery Drug Metabolism and Pharmacokinetics Project Work
Anna-Karin Sohlenius-Sternbeck and Ylva Terelius

Drug Metabolism and Disposition February 2022, 50 (2) 95-104; DOI: https://doi.org/10.1124/dmd.121.000552

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