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Pharmacokinetics and Absorption, Distribution, Metabolism and Excretion of RGLS4326 in Mouse and Monkey, an Anti–miR-17 Oligonucleotide for the Treatment of Polycystic Kidney Disease
Amin Kamel, Tate Owen, Izaiah Cole, Tania Valencia and Edmund C. Lee

Drug Metabolism and Disposition November 2023, 51 (11) 1536-1546; DOI: https://doi.org/10.1124/dmd.123.001446
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Prediction of Drug–Drug Interactions with Ensartinib as a Time-Dependent CYP3A Inhibitor Using Physiologically Based Pharmacokinetic Model
Xiaowen Wang, Yiqun Yu, Hongrui Liu, Fengjiao Bu, Chunying Shen, Qingfeng He, Xiao Zhu, Pin Jiang, Bing Han and Xiaoqiang Xiang

Drug Metabolism and Disposition November 2023, 51 (11) 1515-1526; DOI: https://doi.org/10.1124/dmd.123.001373
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Exploring the Boundaries for In Vitro–In Vivo Extrapolation: Use of Isolated Rat Hepatocytes in Co-culture and Impact of Albumin Binding Properties in the Prediction of Clearance of Various Drug Types
Laura Francis, Kayode Ogungbenro, Tom De Bruyn, J. Brian Houston and David Hallifax

Drug Metabolism and Disposition November 2023, 51 (11) 1463-1473; DOI: https://doi.org/10.1124/dmd.123.001309
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Heterodimerization of Human UDP-Glucuronosyltransferase 1A9 and UDP-Glucuronosyltransferase 2B7 Alters Their Glucuronidation Activities
Jia Xue, Jiayi Yin, Jing Nie, Huidi Jiang, Haitao Zhang and Su Zeng

Drug Metabolism and Disposition November 2023, 51 (11) 1499-1507; DOI: https://doi.org/10.1124/dmd.123.001369
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Goldenseal-Mediated Inhibition of Intestinal Uptake Transporters Decreases Metformin Systemic Exposure in Mice
Victoria O. Oyanna, Kenisha Y. Garcia-Torres, Baron J. Bechtold, Katherine D. Lynch, M. Ridge Call, Miklós Horváth, Preston K. Manwill, Tyler N. Graf, Nadja B. Cech, Nicholas H. Oberlies, Mary F. Paine and John D. Clarke

Drug Metabolism and Disposition November 2023, 51 (11) 1483-1489; DOI: https://doi.org/10.1124/dmd.123.001360
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Metabolism and Excretion of Therapeutic Peptides: Current Industry Practices, Perspectives, and Recommendations
Minxia Michelle He, Sean Xiaochun Zhu, Joe R. Cannon, Jesper Kammersgaard Christensen, Ruchia Duggal, Mithat Gunduz, Constanze Hilgendorf, Adam Hughes, Ivy Kekessie, Maximilian Kullmann, Dennis Leung, Carsten Terjung, Kai Wang and Frank Wesche

Drug Metabolism and Disposition November 2023, 51 (11) 1436-1450; DOI: https://doi.org/10.1124/dmd.123.001437
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Cytochrome P450 enzymes as drug targets in human disease
F. Peter Guengerich

Drug Metabolism and Disposition October 4, 2023, DMD-MR-2023-001431; DOI: https://doi.org/10.1124/dmd.123.001431
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Acetaminophen-Induced Hepatic Necrosis: A Reminiscence
David Jollow

Drug Metabolism and Disposition October 4, 2023, DMD-COM-2023-001278; DOI: https://doi.org/10.1124/dmd.123.001278
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Potential and Challenges in Application of Physiologically Based Pharmacokinetic Modeling in Predicting Diarrheal Disease Impact on Oral Drug Pharmacokinetics
Cindy X. Zhang and Samuel L.M. Arnold

Drug Metabolism and Disposition September 15, 2023, DMD-MR-2022-000964; DOI: https://doi.org/10.1124/dmd.122.000964
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Impact of Heterotropic Allosteric Modulation on the Time-Dependent Inhibition of Cytochrome P450 3A4
Luc R.A. Rougée, David W. Bedwell, Kasi Hansen, Trent L. Abraham and Stephen D. Hall

Drug Metabolism and Disposition October 2023, 51 (10) 1372-1380; DOI: https://doi.org/10.1124/dmd.123.001382

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