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Research ArticleArticle

Substrate-Dependent Inhibition of Organic Anion Transporting Polypeptide 1B1: Comparative Analysis with Prototypical Probe Substrates, Estradiol-17β-Glucuronide, Estrone-3-Sulfate, and Sulfobromophthalein

Saki Izumi, Yoshitane Nozaki, Takafumi Komori, Kazuya Maeda, Osamu Takenaka, Kazutomi Kusano, Tsutomu Yoshimura, Hiroyuki Kusuhara and Yuichi Sugiyama
Drug Metabolism and Disposition August 6, 2013, dmd.113.052290; DOI: https://doi.org/10.1124/dmd.113.052290
Saki Izumi
1 Drug Metabolism and Pharmacokinetics Japan, Tsukuba Research Laboratories, Eisai Co. Ltd.;
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Yoshitane Nozaki
1 Drug Metabolism and Pharmacokinetics Japan, Tsukuba Research Laboratories, Eisai Co. Ltd.;
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Takafumi Komori
1 Drug Metabolism and Pharmacokinetics Japan, Tsukuba Research Laboratories, Eisai Co. Ltd.;
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Kazuya Maeda
2 Graduate School of Pharmaceutical Sciences, The University of Tokyo;
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Osamu Takenaka
1 Drug Metabolism and Pharmacokinetics Japan, Tsukuba Research Laboratories, Eisai Co. Ltd.;
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Kazutomi Kusano
1 Drug Metabolism and Pharmacokinetics Japan, Tsukuba Research Laboratories, Eisai Co. Ltd.;
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Tsutomu Yoshimura
1 Drug Metabolism and Pharmacokinetics Japan, Tsukuba Research Laboratories, Eisai Co. Ltd.;
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Hiroyuki Kusuhara
2 Graduate School of Pharmaceutical Sciences, The University of Tokyo;
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Yuichi Sugiyama
3 Sugiyama Laboratory, RIKEN Innovation Center, Research Cluster for Innovation, RIKEN
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  • For correspondence: ychi.sugiyama@riken.jp

Supplemental Data

Files in this Data Supplement:

  • Supplemental Figure 1 -

    Individual data of mutual inhibition of OATP1B1-mediated uptake of 3HE2G, 3HE1S, and 3HBSP

  • Supplemental Tables -

    Table 1 - Statistical analysis of stimulatory effect of tested compounds on OATP1B1-mediated uptake of 3HE2G

    Table 2 - Statistical analysis of stimulatory effect of tested compounds on OATP1B1-mediated uptake of 3HE1S

    Table 3 - Statistical analysis of stimulatory effect of tested compounds on OATP1B1-mediated uptake of 3HBSP

  View article

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