Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion (MATE1 and MATE2K) as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance

Supplemental Data

Files in this Data Supplement:

• Supplemental Figures -

  Supplemental Figure 1 - Chemical structures of vandetanib (A), gefitinib (B), erlotinib (C), and lapatinib (D)

  Supplemental Figure 2 - Comparison of IC50 values for the inhibition of OCT2-mediated MPP+ uptake versus inhibition of OCT2-mediated metformin uptake (A) and MPP+/metformin IC50 ratios (B).