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Research ArticleArticle

Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs and Humans

Rao N.V.S. Mamidi, Filip Cuyckens, Jie Chen, Ellen Scheers, Dennis Kalamaridis, Ronghui Lin, Jose Silva, Sue Sha, David C. Evans, Michael F. Kelley, Damayanthi Devineni, Mark D. Johnson and Lim Heng Keang
Drug Metabolism and Disposition February 25, 2014, dmd.113.056440; DOI: https://doi.org/10.1124/dmd.113.056440
Rao N.V.S. Mamidi
1 Janssen Research & Development LLC,;
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  • For correspondence: smamidi1@its.jnj.com
Filip Cuyckens
2 Janssen Research & Development, a division of Janssen Pharmaceutica NV;
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Jie Chen
1 Janssen Research & Development LLC,;
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Ellen Scheers
3 3Janssen Research & Development, a division of Janssen Pharmaceutica NV;
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Dennis Kalamaridis
4 Janssen Research & Development, LLC
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Ronghui Lin
4 Janssen Research & Development, LLC
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Jose Silva
4 Janssen Research & Development, LLC
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Sue Sha
4 Janssen Research & Development, LLC
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David C. Evans
4 Janssen Research & Development, LLC
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Michael F. Kelley
4 Janssen Research & Development, LLC
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Damayanthi Devineni
4 Janssen Research & Development, LLC
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Mark D. Johnson
4 Janssen Research & Development, LLC
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Lim Heng Keang
4 Janssen Research & Development, LLC
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Data Supplement

Files in this Data Supplement:

  • Data Supplement -

    Supplemental Method

    Supplemental Figure 1 - Atom numbering scheme for NMR analysis of M5, M7, and M9

    Supplemental Figure 2 - 1H NMR spectra of metabolite M5

    Supplemental Figure 3 - 1H NMR spectra of metabolite M7

    Supplemental Figure 4 - 1H NMR spectra of metabolite M9

    Supplemental Table 1 - NMR Chemical Shifts for M5, M7, and M9

  View article

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