Mechanism-Based Inhibitory and PPARα-Dependent Modulating Effects of Silybin on Principle Hepatic Drug-Metabolizing Enzymes

Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Table 1 - List of primer sequences used for RT-PCR

  Supplemental Figure 1 - Effects of co-administration of silybin and fenofibrate on the mRNA levels of UGTs in HepG2 cells

  Supplemental Figure 2 - mRNA levels of Ugt isozymes in the livers of mice treated with silybin and/or fenofibrate

  Supplemental Figure 3 - Activities of Ugt isozymes in the livers of mice treated with silybin and/or fenofibrate

  Supplemental Figure 4 - Activities of main P450s in the livers of mice treated with silybin for only once