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Research ArticleArticle

A Long-Standing Mystery Solved: The Formation of 3-Hydroxydesloratadine is Catalyzed by CYP2C8 but Prior Glucuronidation of Desloratadine by UGT2B10 is an Obligatory Requirement

Faraz Kazmi, Joanna E Barbara, Phyllis Yerino and Andrew Parkinson
Drug Metabolism and Disposition January 16, 2015, dmd.114.062620; DOI: https://doi.org/10.1124/dmd.114.062620
Faraz Kazmi
1 XenoTech LLC;
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  • ORCID record for Faraz Kazmi
  • For correspondence: fkazmi@xenotechllc.com
Joanna E Barbara
2 Xenotech LLC;
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Phyllis Yerino
1 XenoTech LLC;
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Andrew Parkinson
3 XPD Consulting
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Data Supplement

Files in this Data Supplement:

  • Supplemental Data -

    Supplemental Table 1 - Individual human donor information for CYP2C8 correlation analysis

    Supplemental Figure 1 - Formation of 5- and 6-hydroxydesloratadine in hepatocytes from mouse, rat, rabbit, dog, minipig, monkey and human

    Supplemental Figure 2 - The effect of various P450 chemical inhibitors on 5- hydroxydesloratadine, 6-hydroxydesloratadine and 3-hydroxydesloratadine O-glucuronide formation in cryopreserved human hepatocytes (CHHs)

    Supplemental Figure 3 - Correlation of N-desalkylamodiaquine formation with 6alpha-hydroxypaclitaxel formation in a panel of individual donor cryopreserved human hepatocytes (CHHs)

    Supplemental Figure 4 - Time course of 3-hydroxydesloratadine formation in HLM (0.1 mg/mL) and HS9 (1 mg/mL) with or without NADPH and/or UDP-GlcUA

  View article

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