Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Table 1 - Individual human donor information for CYP2C8 correlation analysis
Supplemental Figure 1 - Formation of 5- and 6-hydroxydesloratadine in hepatocytes from mouse, rat, rabbit, dog, minipig, monkey and human
Supplemental Figure 2 - The effect of various P450 chemical inhibitors on 5- hydroxydesloratadine, 6-hydroxydesloratadine and 3-hydroxydesloratadine O-glucuronide formation in cryopreserved human hepatocytes (CHHs)
Supplemental Figure 3 - Correlation of N-desalkylamodiaquine formation with 6alpha-hydroxypaclitaxel formation in a panel of individual donor cryopreserved human hepatocytes (CHHs)
Supplemental Figure 4 - Time course of 3-hydroxydesloratadine formation in HLM (0.1 mg/mL) and HS9 (1 mg/mL) with or without NADPH and/or UDP-GlcUA