Data Supplement
Files in this Data Supplement:
- Supplemental Figures -
Supplemental Figure 1 - Saturation kinetics for the hydrolysis of GDC-0834 and formation of M1 with (A) human liver cytosol (HLC) and (B) dog liver cytosol (DLC)
Supplemental Figure 2 - IC50 curves of M1 and M2 (0 - 10 mu-M) for aldehyde oxidase-mediated metabolism of probe substrate phthalazine (formation of phthalazinone)...