Abemaciclib (LY2835219) is an Oral Inhibitor of the Cyclin-Dependent Kinases 4/6 that Crosses the Blood-Brain Barrier and Demonstrates In Vivo Activity Against Intracranial Human Brain Tumor Xenografts

Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Table 1A - Experimental values plotted as Figure 2

  Supplemental Table 1B - Experimental values plotted as Figure 2 and shown in Supplement Table 1A

  Supplemental Table 2 - Experimental values (mean total concentration and standard deviation) from the Mouse or Rat Brain Uptake Assay

  Supplemental Figure 1 - Whole-body autoradiograph of Sprague-Dawley rat eight hours after a single oral administration of 10 mg/kg 14C abemaciclib