Species Differences in the Oxidative Desulfuration of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes

Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Figure 1 - Metabolic instability of 1 (1 mu-M) in rat, dog or human liver microsomes in the presence (+) or absence (-) of NADPH co-factor

  Supplemental Figure 2 - MS2 (panel A) and MS3 (panel B) spectra of 1

  Supplemental Figure 3 - MS2 (panel A) and MS3 (panel B) spectra of M1

  Supplemental Figure 4 - MS2 (panel A) and MS3 (panel B) spectra of M2

  Supplemental Figure 5 - Impact of excess GSH (5 mM) on the oxidative desulfuration of 1 (1 mu-M) to M1 in NADPH-supplemented rat

  Supplemental Figure 6 - Plasma concentration versus time profile...