Application of static models to predict midazolam clinical interactions in the presence of single or multiple HCV drugs

Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Methods

  Supplement Figure 1 - Inhibition of CYP3A4 catalyzed midazolam 1'-hydroxylation by HCV compounds

  Supplement Figure 2 - Time dependent inhibition of CYP3A4 catalyzed midazolam 1'-hydroxylation by ASV (each point represents mean of triplicate, error bar represents standard deviation)

  Supplement Table 1 - Kinetic parameters of CYP3A4 inhibition and TDI by ASV, DCV, BCV and BCV-M1 in human liver microsomes

  Supplement Table 2 - Fitting outcomes for the CYP3A4 induction data