Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleArticle

Discovery of a Novel Microsomal Epoxide Hydrolase Catalyzed Hydration of a Spiro Oxetane

Xue-Qing Li, Martin A. Hayes, Gunnar Gronberg, Kristina Berggren, Neal Castagnoli Jr. and Lars Weidolf
Drug Metabolism and Disposition June 2, 2016, dmd.116.071142; DOI: https://doi.org/10.1124/dmd.116.071142
Xue-Qing Li
1 AstraZeneca Gothenburg;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: xueqing.li@astrazeneca.com
Martin A. Hayes
1 AstraZeneca Gothenburg;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gunnar Gronberg
1 AstraZeneca Gothenburg;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kristina Berggren
1 AstraZeneca Gothenburg;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Neal Castagnoli Jr.
2 Virginia Tech
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lars Weidolf
1 AstraZeneca Gothenburg;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site

Data Supplement

Files in this Data Supplement:

  • Supplemental Data -

    NMR characterization of synthesized compound AZ13478123 Methods

    Supplemental Figure 1 - 600 MHz 1H spectra of AZ13478123 (top) and AZD1979 ( bottom) in CD3OD at 25 deg

    Supplemental Figure 2 - 150 MHz 13C spectra of AZ13478123 (top) and AZD1979 (bottom) in CD3OD at 25 deg

    Supplemental Figure 3 - 1H -13C HMBC long-range correlation from CH2(5,7) to CH2(8) of AZ13478123

    Supplemental Table 1 - NMR assignments for 3-(4-{3,3-bis(hydroxymethyl)azetidin-1- ylmethyl}phenoxy)azetidin-1-yl5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-ylmethanone (AZ13478123) and AZD1979

    Supplemental Figure 4 - Comparison of extracted ion chromatograms of AZD1979 and M1 (mass tolerance 10 ppm) in samples without (A and C) and with (B and D) the spiking of the synthesized diol, AZ13478123

  View article

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics