Evaluation of CYP2B6 Induction and Prediction of Clinical DDI: Considerations from the IQ Consortium Induction Working Group- An Industry Perspective

Data Supplement

Files in this Data Supplement:

• Supplemental Tables -

  Supplemental Table 1 - Representative plating conditions and data end points used by companies for conducting CYP2B6 and CYP3A4 enzyme induction analysis

  Supplemental Table 2 - Representative CYP2B6 enzyme induction Emax and EC50 values in response to various tested xenobiotic

  Supplemental Table 3 - Representative CYP3A4 enzyme induction Emax and EC50 values in response to various tested xenobiotic

  Supplemental Table 4 - Source and hepatocyte lots used

  Supplemental Table 5 - Precipitant drug input parameters for simcyp simulations