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Research ArticleArticle

In Vitro and in Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity

Johan Monbaliu, Martha Gonzalez, Apexa Bernard, James Jiao, Carlo Sensenhauser, Jan Snoeys, Hans Stieltjes, Inneke Wynant, Johan W Smit and Caly Chien
Drug Metabolism and Disposition August 8, 2016, dmd.116.070672; DOI: https://doi.org/10.1124/dmd.116.070672
Johan Monbaliu
Janssen Research & Development
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Martha Gonzalez
Janssen Research & Development
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Apexa Bernard
Janssen Research & Development
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James Jiao
Janssen Research & Development
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Carlo Sensenhauser
Janssen Research & Development
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Jan Snoeys
Janssen Research & Development
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Hans Stieltjes
Janssen Research & Development
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Inneke Wynant
Janssen Research & Development
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Johan W Smit
Janssen Research & Development
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Caly Chien
Janssen Research & Development
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  • For correspondence: cchien@its.jnj.com

Data Supplement

Files in this Data Supplement:

  • Supplemental Figures -

    Supplemental Figure 1 - Chemical structures of abiraterone acetate, abiraterone, and the main metabolites in humans in the proposed main biotransformation pathway...

    Supplemental Figure 2 - Chemical structures of pioglitazone, M-IV, and M-III...

  View article

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