Hepatic dipeptidyl peptidase-4 controls pharmacokinetics of vildagliptin in vivo

Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Table 1 - Characteristics of 23 donors used in this study

  Supplemental Table 2 - Primer sequences used for real-time RT-PCR analyses

  Supplemental Figure 1 - Body weight (A), blood glucose (B), and plasma DPP-4 activity (C) in STZ-induced diabetic mice

  Supplemental Figure 2 - Correlation analysis between hepatic vildagliptin-hydrolyzing activities and protein expression levels of CYP3A4 in individual HLMs