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Research ArticleMinireview

Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism.

Andrew J Annalora, Craig B Marcus and Patrick L Iversen
Drug Metabolism and Disposition February 10, 2017, dmd.116.073254; DOI: https://doi.org/10.1124/dmd.116.073254
Andrew J Annalora
Oregon State University
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  • ORCID record for Andrew J Annalora
  • For correspondence: andrew.annalora@oregonstate.edu
Craig B Marcus
Oregon State University
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Patrick L Iversen
Oregon State University
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Data Supplement

Files in this Data Supplement:

  • Supplemental Data -

    Supplemental Discussion

    Supplemental References

    Supplemental Table 1 - CYP Transcript Variant Subcellular Localization

    Supplemental Table 2 - Therapeutic Applications of Splice-Switching Oligonucleotides

    Supplemental Figure 1 - Schematic Diagram of the Alternative Gene Splicing Process

    Supplemental Figure 2 - Alternative Splicing and Function of the CYP1B1 Gene

    Supplemental Figure 3 - Alternative-Splicing of the Human CYP19A1: Tissue-specific Exon 1 and 5 Inclusion

    Supplemental Figure 4 - Alternative Splicing of Human Drug Metabolizing P450s: CYP2C9 and CYP2D6

    Supplemental Figure 5 - Trans-Splicing of the Human CYP3A Gene Family: Cryptic Alternative Exon 1 Usage

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