Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism.

Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Discussion

  Supplemental References

  Supplemental Table 1 - CYP Transcript Variant Subcellular Localization

  Supplemental Table 2 - Therapeutic Applications of Splice-Switching Oligonucleotides

  Supplemental Figure 1 - Schematic Diagram of the Alternative Gene Splicing Process

  Supplemental Figure 2 - Alternative Splicing and Function of the CYP1B1 Gene

  Supplemental Figure 3 - Alternative-Splicing of the Human CYP19A1: Tissue-specific Exon 1 and 5 Inclusion

  Supplemental Figure 4 - Alternative Splicing of Human Drug Metabolizing P450s: CYP2C9 and CYP2D6

  Supplemental Figure 5 - Trans-Splicing of the Human CYP3A Gene Family: Cryptic Alternative Exon 1 Usage