Metabolite Identification, Reaction Phenotyping and Retrospective Drug-Drug Interaction Predictions of 17-deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate

Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplementary Figure 1 - Disappearance of NGMN in all tested recombinant cytochrome P450s (A) and NG in all the tested recombinant cytochrome P450s (B) and UGTs (C)

  Supplementary Figure 2 - HRMS spectra of NGMN along with structure elucidation of metabolites

  Supplementary Figure 3 - HRMS spectra of NG along with structure elucidation of metabolites

  Supplementary Figure 4 - Reaction phenotyping of NG in rCYPs showing % metabolite formation in respective CYP isoform

  LC-MS Analysis