Interaction and Transport of Methamphetamine and its Primary Metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters

Data Supplement

• Supplemental Data -

  Supplemental Figure 1 - Metformin uptake by hOCT1, hOCT2, hOCT3, hMATE1, and hMATE2-K in Flp-in HEK293 cells in the presence or absence of the prototypical inhibitor cimetidine

  Supplemental Figure 2 - Replica studies of methamphetamine, amphetamine, and p-OHMA inhibition of hOCT1, hOCT2, hOCT3, hMATE1, and hMATE2-K

  Supplemental Figure 3 - Inhibition of hOCT1 and hOCT2 by methamphetamine and amphetamine fitted to a two binding site model

  Supplemental Figure 4 - Replica studies on methamphetamine, amphetamine, and p-OHMA uptake kinetics by hOCTs

  Supplemental Figure 5 - Replica studies of methamphetamine (A-D), amphetamine (E-F), and p-OHMA (I & J) uptake kinetics by hMATE1 and hMATE2-K