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Drug Metabolism & Disposition

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Research ArticlePerspective

Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on Down-regulation, CYP2C Induction and CYP2B6 Positive Control

Niresh Hariparsad, Diane Ramsden, Jairam Palamanda, Joshua G Dekeyser, Odette A Fahmi, Jane R Kenny, Heidi Einolf, Michael Mohutsky, Magalie Pardon, Amy Y Siu, Liangfu Chen, Michael Sinz, Barry Jones, Robert Walsky, Shannon Dallas, Suresh K Balani, George Zhang, David Buckley and Donald Tweedie
Drug Metabolism and Disposition June 23, 2017, dmd.116.074567; DOI: https://doi.org/10.1124/dmd.116.074567
Niresh Hariparsad
1 Vertex Pharmaceuticals;
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  • For correspondence: niresh_hariparsad@vrtx.com
Diane Ramsden
2 Boehringer Ingelheim;
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Jairam Palamanda
3 Merck and Co;
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Joshua G Dekeyser
4 Amgen;
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Odette A Fahmi
5 Pfizer;
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Jane R Kenny
6 Genentec;
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Heidi Einolf
7 Novartis;
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Michael Mohutsky
8 Eli Lilly;
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Magalie Pardon
9 Sanofi;
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Amy Y Siu
10 Eisai;
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Liangfu Chen
11 GSK;
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Michael Sinz
12 BMS;
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Barry Jones
13 AstraZenecca;
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Robert Walsky
14 EMD Serono;
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Shannon Dallas
15 Janssen R&D;
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Suresh K Balani
16 Takeda;
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George Zhang
17 Corning Life Sciences;
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David Buckley
18 XenoTech LLC
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Donald Tweedie
3 Merck and Co;
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Data Supplement

  • Supplemental Data -

    Supplementary Table 1 - Induction of CYP2C and CYP3A mRNA in Human Hepatocytes Following Treatment with Xenobiotics for 48 hrs

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