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Research ArticleArticle

Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase (UGT) Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

Brahim Achour, Alyssa Dantonio, Mark Niosi, Jonathan J. Novak, John K. Fallon, Jill Barber, Philip C. Smith, Amin Rostami-Hodjegan and Theunis C. Goosen
Drug Metabolism and Disposition August 2, 2017, dmd.117.076703; DOI: https://doi.org/10.1124/dmd.117.076703
Brahim Achour
1 University of Manchester;
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Alyssa Dantonio
2 Pfizer Inc.;
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Mark Niosi
2 Pfizer Inc.;
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Jonathan J. Novak
2 Pfizer Inc.;
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John K. Fallon
3 University of North Carolina at Chapel Hill;
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Jill Barber
1 University of Manchester;
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Philip C. Smith
3 University of North Carolina at Chapel Hill;
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Amin Rostami-Hodjegan
1 University of Manchester;
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Theunis C. Goosen
4 Pfizer, Inc.
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  • For correspondence: theunis.goosen@pfizer.com

Data Supplement

  • Supplemental Data -

    Statistical analysis (additional information)

    Supplemental Table 1 - Demographic and clinical details of the individual liver donors: Techniques used to characterize the samples are shown in color

    Supplemental Table 2 - Summary of intra- and inter-day technical variability for peptides used in the SIL and QconCAT methods

    Supplemental Table 3 - Summary of the quantitative analysis of the set of UGT enzymes with differences between the matched datasets (n=23-24)

    Supplemental Table 4 - Correlation matrix of SIL-derived individual UGT enzyme abundances with activity rates (abundance vs activity)

    Supplemental Table 5 - Correlation matrix of QconCAT-derived individual UGT enzyme abundances with activity rates (abundance vs activity)

    Supplemental Table 6 - Correlation matrix of individual protein abundances of UGT enzymes (abundance vs abundance) using the two different methodologies

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