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Research ArticleArticle

Elucidation of the impact of P-glycoprotein and Breast Cancer Resistance Protein on the brain distribution of catechol-O-methyltransferase inhibitors

Joana Bicker, Ana Fortuna, Gilberto Alves, Patricio Soares-da-Silva and Amilcar Falcao
Drug Metabolism and Disposition September 15, 2017, dmd.117.077883; DOI: https://doi.org/10.1124/dmd.117.077883
Joana Bicker
1 Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal;
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Ana Fortuna
1 Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal;
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Gilberto Alves
2 Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilha, Portugal;
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  • For correspondence: gilberto@fcsaude.ubi.pt
Patricio Soares-da-Silva
3 Department of Research and Development, BIAL, 4745-457, S. Mamede do Coronado, Portugal
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Amilcar Falcao
1 Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal;
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Data Supplement

  • Supplemental Tables -

    Supplemental Table 1 - Chromatographic conditions and validation parameters of HPLC-DAD techniques applied for the quantification of reference and test compounds in samples from in vitro and in vivo assays

    Supplemental Table 2 - Stability (values in percentage) of COMT inhibitors in HBSS with 10mM HEPES pH 7.4 under cellular assay conditions (37ยบ C for 120 min)

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