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Drug Metabolism & Disposition

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Research ArticleArticle

Expression and functional characterization of breast cancer-associated cytochrome P450 4Z1 in Saccharomyces cerevisiae

Matthew G McDonald, Sutapa Ray, Clara J. Amorosi, Katherine A. Sitko, John P. Kowalski, Lorela Paco, Abhinav Nath, Byron M. Gallis, Rheem A. Totah, Maitreya J. Dunham, Douglas M. Fowler and Allan E. Rettie
Drug Metabolism and Disposition October 10, 2017, dmd.117.078188; DOI: https://doi.org/10.1124/dmd.117.078188
Matthew G McDonald
University of Washington
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Sutapa Ray
University of Washington
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Clara J. Amorosi
University of Washington
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Katherine A. Sitko
University of Washington
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John P. Kowalski
University of Washington
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Lorela Paco
University of Washington
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Abhinav Nath
University of Washington
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Byron M. Gallis
University of Washington
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Rheem A. Totah
University of Washington
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Maitreya J. Dunham
University of Washington
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Douglas M. Fowler
University of Washington
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Allan E. Rettie
University of Washington
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  • For correspondence: rettie@uw.edu

Data Supplement

  • Supplemental Data -

    Supplemental Table 1 - Primers used for vector construction

    Supplemental Figure 1 - Plasmid sequences

    Supplemental Figure 2 - ESI- LC-MS/MS chromatograms showing AA metabolism by CYP4F12 Supersomes

    Supplemental Figure 3 - HET0016 inhibition of CYP4F12-catalyzed AA metabolism

  View article

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