Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys

Data Supplement

• Supplemental Data -

  Supplementary Table 1 - Comparison of Plasma Concentrations of Selected Endogenous Metabolites between a Single or Combined IV Administration of PROB (40 mg/kg) and FSM with a Single IV Administration of 2 mg/kg FSM in 3 Cynomolgus Monkeys
  

  Supplementary Table 2 - Comparison of Inhibition Potency of PROB Towards Various Human Transporters
  

  Supplementary Figure 1 - Time course of uptake of PDA (1 μM) by OAT1 (A) and OAT3 (B), and HVA (5 μM) by OAT1
  

  Supplementary Figure 2 - Profiling of the transport of PDA and HVA by major drug transporters expressed at the basolateral membrane of human hepatocytes