Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation

Data Supplement

• Supplemental Figures -

  Supplemental Figure 1- Concentration-dependent inhibition of intestinal microsomal UGT activity (4-MU glucuronidation) by purified catechins
  

  Supplemental Figure 2 - Dixon plots showing inhibition of raloxifene-4'-glucuronide (R4G; left) or raloxifene-6-glucuronide (R6G; right) formation by ECG (upper) and EGCG (lower)
  

  Supplemental Figure 3 - Concentration-dependent inhibition of intestinal microsomal UGT activity (raloxifene glucuronidation) by purified catechins