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Research ArticleShort Communication

Mouse hepatomas with Ha-ras and B-raf mutations differ in mitogen-activated protein kinase signaling and response to constitutive androstane receptor activation

Albert Braeuning, Ferdinand Kollotzek, Eva Zeller, Thomas Knorpp, Markus F. Templin and Michael Schwarz
Drug Metabolism and Disposition August 16, 2018, dmd.118.083014; DOI: https://doi.org/10.1124/dmd.118.083014
Albert Braeuning
1 German Federal Institute for Risk Assessment, Dept. Food Safety;
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  • For correspondence: albert.braeuning@bfr.bund.de
Ferdinand Kollotzek
2 University of Tuebingen, Dept. of Toxicology;
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Eva Zeller
2 University of Tuebingen, Dept. of Toxicology;
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Thomas Knorpp
3 Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen
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Markus F. Templin
3 Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen
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Michael Schwarz
2 University of Tuebingen, Dept. of Toxicology;
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Data Supplement

  • Supplemental Data -

    Supplemental Figure 1 - Schematic representation (not to scale) of the treatment protocol

    Supplemental Figure 2 - Western Blot verification of differential expression of the CAR targets in normal liver (NL) and in mouse liver tumors with activating mutations in either Ha-ras (Ras) or B-raf (Raf)

    Supplemental Figure 3 - CAR mRNA levels in normal liver (NL) and mouse liver tumors with activating mutations in either Ha-ras (Ras) or B-raf (Raf)

    Supplementary Table 1 - Antibodies used for RPPA assay

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