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Research ArticleArticle

The importance of incorporating OCT2 plasma membrane expression and membrane potential in IVIVE of metformin renal secretory clearance

Vineet Kumar, Jia Yin, Sarah Billington, Bhagwat Prasad, Colin Brown, Joanne Wang and Jashvant D. Unadkat
Drug Metabolism and Disposition August 9, 2018, dmd.118.082313; DOI: https://doi.org/10.1124/dmd.118.082313
Vineet Kumar
1 University of Washington;
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Jia Yin
1 University of Washington;
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Sarah Billington
2 Newcastle University
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Bhagwat Prasad
1 University of Washington;
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Colin Brown
2 Newcastle University
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Joanne Wang
1 University of Washington;
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Jashvant D. Unadkat
1 University of Washington;
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  • For correspondence: jash@uw.edu

Data Supplement

  • Supplemental Data -

    Materials and Methods

    Supplemental Table 1 - MRM parameters used for quantification of OCT2 and marker proteins

    Supplemental Table 2 -  Renal clearance (CLr) of metformin in healthy human subjects

    Supplemental References

  View article

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