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Drug Metabolism & Disposition

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Research ArticleArticle

Assessment of the Biotransformation of Low Turnover Drugs in the HμREL Human Hepatocyte Coculture Model

Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler
Drug Metabolism and Disposition August 22, 2018, dmd.118.082867; DOI: https://doi.org/10.1124/dmd.118.082867
Richard D. Burton
1 Q2 Solutions, a Quintiles Quest Joint Venture;
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Todd Hieronymus
1 Q2 Solutions, a Quintiles Quest Joint Venture;
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Taysir Chamem
1 Q2 Solutions, a Quintiles Quest Joint Venture;
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David Heim
1 Q2 Solutions, a Quintiles Quest Joint Venture;
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Shelby Anderson
1 Q2 Solutions, a Quintiles Quest Joint Venture;
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Xiaochun Zhu
1 Q2 Solutions, a Quintiles Quest Joint Venture;
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J. Matthew Hutzler
2 Q2 Solutions, Bioanalytical & ADME Labs
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  • For correspondence: matt.hutzler@q2labsolutions.com

Data Supplement

  • Supplemental Table -

    Fragmentation of Parent Drug and Key Fragment Ions of Metabolites

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