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Research ArticleShort Communication

Identification of 19-(S/R)Hydroxyeicosatetraenoic Acid as the First Endogenous Non-Competitive Inhibitor of Cytochrome P450 CYP1B1 with Enantioselective Activity

Sherif M. Shoieb, Ahmed A. El-Sherbeni and Ayman O.S. El-Kadi
Drug Metabolism and Disposition November 12, 2018, dmd.118.084657; DOI: https://doi.org/10.1124/dmd.118.084657
Sherif M. Shoieb
1 University of Alberta;
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Ahmed A. El-Sherbeni
2 University of Toronto and Tanta University
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Ayman O.S. El-Kadi
1 University of Alberta;
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  • ORCID record for Ayman O.S. El-Kadi
  • For correspondence: aelkadi@pharmacy.ualberta.ca

Data Supplement

  • Supplemental Figures -

    Supplemental Figure 1 - Representative LC-MS chromatograms showing the peaks of 19(R)-HETE and internal standard at the start of the experiment (a), after 10 min (b), 20 min (c) and 30 min (d)

    Supplemental Figure 2 - Representative LC-MS chromatograms showing the peaks of 19(S)-HETE and internal standard at the start of the experiment (a), after 10 min (b), 20 min (c) and 30 min (d).

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