Hydrolytic Metabolism of Cyanopyrrolidine DPP-4 Inhibitors Mediated by Dipeptidyl Peptidases

Data Supplement

• Supplemental Figures -

  Supplemental Figure 1 - The typical product ion scan spectra of M0 (A, besigliptin), M2 (B, besigliptin-COOH), and M8-2 (C, besigliptin-amide)

  Supplemental Figure 2 - The formation of besigliptin-COOH from besigliptin (5 mu-M) in rat plasma with or without saxagliptin (100 mu-M) at 37degrees C for 3 h (n=3)

  Supplemental Figure 3 - Hydrolysis of besigliptin (250 nM) in DPP-4, DPP-2, DPP-8, Dpp-9, FAP