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Research ArticleArticle

In Silico Prediction of the Absorption and Disposition of Cefadroxil in Humans using an Intestinal Permeability Method Scaled from Humanized PepT1 Mice

Yongjun Hu and David E Smith
Drug Metabolism and Disposition December 28, 2018, dmd.118.084236; DOI: https://doi.org/10.1124/dmd.118.084236
Yongjun Hu
1 University of Michigan;
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David E Smith
2 The University of Michigan
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  • For correspondence: smithb@umich.edu

Data Supplement

  • Supplemental Data -

    Method to Estimate the Concentration-Dependent Permeability of Cefadroxil in Mouse
    Intestinal Segments during Single Escalating Doses and during Multiple Dosing

    Supplemental Table 1 - Model fitting of permeability parameters in wildtype (WT) and humanized (hu) PepT1 mice

    Supplemental Table 2 - Observed and predicted intestinal Peff of cefadroxil in wildtype (WT) and humanized (hu) PepT1 mice when estimated by the in situ permeability of small and large intestines

    Supplemental Figure 1 - The concentration-dependent jejunal permeability of cefadroxil in wildtype (panel A) and humanized mice (panel B)

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