In Silico Prediction of the Absorption and Disposition of Cefadroxil in Humans using an Intestinal Permeability Method Scaled from Humanized PepT1 Mice

Data Supplement

• Supplemental Data -

  Method to Estimate the Concentration-Dependent Permeability of Cefadroxil in Mouse
  Intestinal Segments during Single Escalating Doses and during Multiple Dosing
  

  Supplemental Table 1 - Model fitting of permeability parameters in wildtype (WT) and humanized (hu) PepT1 mice

  Supplemental Table 2 - Observed and predicted intestinal Peff of cefadroxil in wildtype (WT) and humanized (hu) PepT1 mice when estimated by the in situ permeability of small and large intestines

  Supplemental Figure 1 - The concentration-dependent jejunal permeability of cefadroxil in wildtype (panel A) and humanized mice (panel B)