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Drug Metabolism & Disposition

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Research ArticleArticle

A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes vs. Human Liver Tissue Using Quantitative Targeted Proteomics and Cell-Surface Biotinylation

Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat
Drug Metabolism and Disposition January 8, 2019, dmd.118.084988; DOI: https://doi.org/10.1124/dmd.118.084988
Vineet Kumar
1 University of Washington;
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  • ORCID record for Vineet Kumar
Laurent Salphati
2 Genentech, Inc.;
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Cornelis E. C. A. Hop
2 Genentech, Inc.;
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Guangqing Xiao
3 Biogen Idec;
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Yurong Lai
4 Gilead Sciences, Inc.;
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Anita Mathias
4 Gilead Sciences, Inc.;
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Xiaoyan Chu
5 Merck & Co., Inc.;
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W. Griffith Humphreys
6 Bristol-Myers Squibb Company;
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Mingxiang Liao
7 Takeda Pharmaceuticals International Co.;
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Scott Heyward
8 BioIVT
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Jashvant D. Unadkat
1 University of Washington;
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  • For correspondence: jash@uw.edu

Data Supplement

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    3 supplemental figures, 4 tables. 

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