Data Supplement
- Supplemental Data -
Supplementary Figure 1 - Schematic diagram of the clinical study protocol.
Supplementary Figure 2 - Eadie-Hofstee plot for the OATP1B1-mediated uptake of [3H]E217βG in the absence and presence of paclitaxel, and fitted parameters.
Supplementary Figure 3 - Inhibitory effect of concomitant drugs on the uptake by HEK293 cells stably expressing OATP1B1/1B3.
Supplementary Figure 4 - Inhibitory effect of paclitaxel on the uptake by HEK293 cells stably expressing hOAT1 and hOAT3.
Supplementary Figure 5 - Comparison of the unbound plasma concentration of paclitaxel with the Ki values for OATP1B1 and OATP1B3.
Supplementary Figure 6 - Effect of paclitaxel pre-incubation on the uptake of [3H]E217βG by HEK293 cells stably expressing OATP1B1.
Supplementary Figure 7 - Protein expression of OATP1B1 and OATP1B3 after incubation with PMA or paclitaxel.
Supplementary Figure 8 - Effect of 6-hydroxy paclitaxel on the uptake of OATP1B1- and OATP1B3mediated [3H]E217βG uptake in HEK293 cells.
Supplementary Figure 9 - Effect of paclitaxel on the OATP1B3-mediated uptake in HEK293 cells.
Supplementary Figure 10 - Effect of SLCO1B1 genotypes on the AUC ratio for the endogenous OATP1B substrates.
Supplementary Figure 11 - Correlation between the biochemical test results, and AUC ratio of CPI.
Supplementary Methods
Supplementary Table 1 - Effect of paclitaxel on AUC–3–7h of C4 and bile acids.