Concentration dependency of the unbound partition coefficient Kp_uu and its application to correct for exposure related discrepancies between biochemical and cellular potency of KAT6A inhibitors

Data Supplement

• Supplemental Figures -

  Supplementary Figure 1 -  Chemical structure of previously published KAT6A inhibitors WM-8014 (A) and WM-1119 (B) that were included in this study.

  Supplementary Figure 2 - Concentration dependent cellular accumulation ratio (Kp) in
  ZR75-1 cells for all investigated KAT6A inhibitors in this study (A-L).

  Supplementary Figure 3 - Concentration dependent Kpuu,cyto determined with the saturation method and observed in vitro potency against ZR75-1 cells for all KAT6A inhibitors in this study (A-L).