Data Supplement
- Supplemental Data -
Supplementary Methods
Supplementary Table 1 - Accurate Mass Values and Characteristic Product Ions for LY3202626 and Metabolites Observed in Rat, dog and Human.
Supplementary Table 2 - Effect of ABT and hydralazine on the formation of M2 following M16 (LSN3420637) incubation in hepatocytes for 4 hours.
Supplementary Table 3A - Relative Distribution of Radioactivity (%) Among Plasma Metabolites Identified in the Radioprofiles of Male Sprague Dawley Rat Plasma After a Single Oral Dose of 30 mg/kg [14C]LY3202626.
Supplementary Table 3B - Relative Distribution of Radioactivity (%) Among Plasma Metabolites Identified in the Radioprofile of Dog Plasma following a Single Intravenous Dose of 1 mg/kg [14C]LY3202626 and a Single Oral Dose of 10 mg/kg [14C]LY3202626 administration.
Supplementary Table 4 - Metabolites Identified in urine, bile and/or feces across rat, dog and human (% dose excretion).
Supplementary Figure 1A - Mean (± SD) cumulative percent of radioactive dose in urine and feces after a single 30 mg/kg oral administration of [14C]LY3202626 hydrate to intact and bile duct cannulated rats.
Supplementary Figure 1B - Mean (± SD) cumulative percent of radioactive dose in urine and feces after a single 10 mg/kg oral and 1 mg/kg intravenous administration of [14C]LY3202626 hydrate to dogs.
Supplementary References