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OtherArticle

Multi-omics profiling reveals protective function of Schisandra lignans against acetaminophen-induced hepatotoxicity

Caixia Yan, Huimin Guo, Qingqing Ding, Yuhao Shao, Dian Kang, Tengjie Yu, Changjian Li, Haoran Huang, Yisha Du, He Wang, Kangrui Hu, Lin Xie, Guangji Wang and Yan Liang
Drug Metabolism and Disposition July 27, 2020, DMD-AR-2020-000083; DOI: https://doi.org/10.1124/dmd.120.000083
Caixia Yan
1China Pharmaceutical University, China
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Huimin Guo
1China Pharmaceutical University, China
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Qingqing Ding
2First Affiliated Hospital of Nanjing Medical University (Jiangsu People's Hospital), China
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Yuhao Shao
1China Pharmaceutical University, China
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Dian Kang
1China Pharmaceutical University, China
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Tengjie Yu
1China Pharmaceutical University, China
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Changjian Li
1China Pharmaceutical University, China
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Haoran Huang
1China Pharmaceutical University, China
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Yisha Du
1China Pharmaceutical University, China
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He Wang
1China Pharmaceutical University, China
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Kangrui Hu
1China Pharmaceutical University, China
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Lin Xie
1China Pharmaceutical University, China
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Guangji Wang
1China Pharmaceutical University, China
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Yan Liang
3Key Lab of Drug Metabolism & Pharmacokinetics, China Pharmaceutical University, China
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  • For correspondence: liangyan0679@163.com

Data Supplement

  • Supplemental Data -

    Supplementary Table 1 - The contents of schizandrol A, schizandrol B, schisantherin A, schizandrin A, schizandrin B in SLE.

    Supplementary Table 2 - The primer sets for the target genes.

    Supplementary Figure 1 - The effect of SLE on liver pathological sections (A), intrahepatic ALT (B) and AST (C) of mice via intragastric administration of SLE (500 mg/kg) twice a day for 3 consecutive days.

    Supplementary Table 3 - Metabolism pathways of APAP induced hepatotoxicity and hepatoprotective effect of SLE.

    Supplementary Table 4 - Fold change of DAGs in APAP-induced liver injury and SLE-treated mice.

    Supplementary Table 5 - Fold change of TAGs in APAP-induced liver injury and SLE-treated mice.

  View article

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