Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
OtherArticle

Organic cation transporter 1 and 3 contribute to the high accumulation of dehydrocorydaline in the heart

Yingchun Chen, Cui Li, Yaodong Yi, Weijuan Du, Huidi Jiang, Su Zeng and Hui Zhou
Drug Metabolism and Disposition July 28, 2020, DMD-AR-2020-000025; DOI: https://doi.org/10.1124/dmd.120.000025
Yingchun Chen
1Laboratory of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cui Li
1Laboratory of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yaodong Yi
2Zhejiang University, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Weijuan Du
1Laboratory of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Huidi Jiang
3College of Pharmaceutical Sciences, Zhejiang University, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Su Zeng
3College of Pharmaceutical Sciences, Zhejiang University, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hui Zhou
2Zhejiang University, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: zhouhui@zju.edu.cn

Data Supplement

  • Supplemental Data  -

    Supplementary Table 1 - Primer list for qRT- PCR.

    Supplementary Table 2 - Inhibitory concentration (IC50) or substrate affinity (Km) of various compounds on organic cation transporters and efflux transporter.

    Supplementary Table 3 - THP concentrations were detected in mice with a single tail vein injection after 15 min.

    Supplementary Figure 1 - The HPLC-DAD chromatogram of the Corydalis yanhusuo extract is presented.

    Supplementary Figure 2 - Accumulation of probe substrates in mock cells and transgenic cells.

    Supplementary Figure 3 - OCT1 and OCT3 are expressed in the rat heart.

    Supplementary Figure 4 - DHC concentration dependently reduced the accumulation of MPP+. 










  View article

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics