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OtherArticle

In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In vitro to In vivo Extrapolation

Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill J Smith and Yurong Lai
Drug Metabolism and Disposition October 9, 2020, DMD-AR-2020-000163; DOI: https://doi.org/10.1124/dmd.120.000163
Xiaomin Liang
1Drug Metabolism, Gilead Sciences Inc., United States of America
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Yeojin Park
2Gilead Sciences Inc, United States of America
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Natalie DeForest
2Gilead Sciences Inc, United States of America
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Jia Hao
2Gilead Sciences Inc, United States of America
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Xiaofeng Zhao
2Gilead Sciences Inc, United States of America
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Congrong Niu
2Gilead Sciences Inc, United States of America
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Kelly Wang
2Gilead Sciences Inc, United States of America
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Bill J Smith
3Gilead Sciences, Inc., United States of America
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Yurong Lai
1Drug Metabolism, Gilead Sciences Inc., United States of America
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  • ORCID record for Yurong Lai
  • For correspondence: yurong.lai@gilead.com

Data Supplement

  • Supplemental Data -

    Supplementary Table 1 - Human primary hepatocyte donor demographics.

    Supplementary Table 2 - Monkey primary hepatocyte donor demographics.

    Supplementary Table 3 - LC-MS/MS conditions.

    Supplementary Table 4 - Protein binding in human and monkey serum.

    Supplementary Figure 1 - The time-course profile for the hepatic uptake. The error bars were represented standard deviation of triplicates.

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