Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
OtherArticle

Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach

Vineet Kumar, Mengyue Yin, Kazuya Ishida, Laurent Salphati, Cornelis E.C.A. Hop, Christopher Rowbottom, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Zsuzsanna Nerada, Nóra Szilvásy, Scott Heyward and Jashvant D. Unadkat
Drug Metabolism and Disposition October 13, 2020, DMD-AR-2020-000204; DOI: https://doi.org/10.1124/dmd.120.000204
Vineet Kumar
1Univiersity of Washington, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mengyue Yin
2University of Washington, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kazuya Ishida
3Gilead Sciences, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laurent Salphati
4Genentech, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cornelis E.C.A. Hop
4Genentech, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher Rowbottom
5DMPK, Biogen Inc., United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Guangqing Xiao
6Biogen Idec, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yurong Lai
7Drug Metabolism, Gilead Sciences Inc., United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yurong Lai
Anita Mathias
8Clinical Pharmacology, Gilead Sciences, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiaoyan Chu
9Drug Metabolism, Merck & Co., United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W. Griffith Humphreys
10PCO, Aranmore Pharma Consultancy, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mingxiang Liao
11DMPK, Takeda, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zsuzsanna Nerada
12SOLVO Biotechnology, Hungary
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nóra Szilvásy
12SOLVO Biotechnology, Hungary
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Scott Heyward
13RnD, Bioreclamation IVT, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jashvant D. Unadkat
14Department of Pharmaceutics, University of Washington, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jashvant D. Unadkat
  • For correspondence: jash@uw.edu

Data Supplement

  • Supplemental Figures -

    Supplementary Figure 1 - [3H]RSV CLint,passive in transporter-expressing cells and hepatocyte models was not significantly different (Tukey's multiple comparisons test). Data for hepatocyte models are mean±SD (n=4), each conducted in triplicate. 

    Supplementary Figure 2 - IVIVE of RSV hepatic CLuptake, in vivo adjusted for the protein-mediated uptake of RSV in transporter-expressing cells assuming sinusoidal uptake CL is the RDS.

  View article

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics