Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach

Data Supplement

• Supplemental Figures -

  Supplementary Figure 1 - [3H]RSV CLint,passive in transporter-expressing cells and hepatocyte models was not significantly different (Tukey's multiple comparisons test). Data for hepatocyte models are mean±SD (n=4), each conducted in triplicate. 
  

  Supplementary Figure 2 - IVIVE of RSV hepatic CLuptake, in vivo adjusted for the protein-mediated uptake of RSV in transporter-expressing cells assuming sinusoidal uptake CL is the RDS.