Extension of the mechanistic tissue distribution model of Rodgers & Rowland by systematic incorporation of lysosomal trapping: impact on Kpu and volume of distribution predictions in the rat

Data Supplement

• Supplemental Tables -

  Supplementary Table 1 - Compound specific parameters of LC-MS/MS quantification

  Supplementary Table 2 - Gradients of high performance liquid chromatography

  Supplementary Table 3 - Physicochemical properties of 26 compounds to predict distribution to lysosomes in rat hepatocytes. 

  Supplementary Table 4 - Tissue:  Plasma water partition coefficients (Kpu) and volume of distributions at steady state Vu,ss) in rat for 28 moderate to strong bases.

  Supplementary Table 5 - Tissue:  Plasma water partition coefficients (Kpu) and unbound volume of distributions at steady state Vu,ss) in rat for 13 moderate to strong protein kinase inhibitors.