Data Supplement
- Supplemental Data -
Supplemental Materials and Methods
Supplemental Table S1 - Donor information for UGT1A1-genotyped human liver microsomes.
Supplemental Figure S1 - LC-MS/MS analysis of debenzylated lapatinib (M1) glucuronide conjugate.
Supplemental Figure S2 - Time-course for formation of lapatinib M1 quinoneimineGSH conjugate in pooled human liver microsomes.
Supplemental Figure S3 - LC-MS/MS analysis of M1 and d4-M1 derived quinoneimine-GSH conjugates.
Supplemental Figure S4 - Representative LC-SRM chromatograms from analysis of M1, d4-M1, and the corresponding quinoneimine-GSH conjugates.
Supplemental Figure S5 - Representative LC-SRM chromatograms of M1, M3, M1-sulfate, and M1-glucuronide.
Supplemental Figure S6 - M1-glucuronide hydrolysis by treatment with bglucuronidase/arylsulfatase.
Supplemental Figure S7 - M1-sulfate hydrolysis by treatment with bglucuronidase/arylsulfatase.
Supplemental References