Data Supplement
- Supplemental Data -
Mean (SD) Plasma Total Dabigatran Concentration Profile over Time (Linear Scale)Supplemental Methods
Supplemental Table 1 - Anionic Probes (Test Acids).
Supplemental Table 2 - Gastric pH Study Subject Disposition.
Supplemental Table 3 - Gastric pH Study Demographics and Baseline Characteristics
Supplemental Table 4 -Test Drugs with pH-Dependent Solubility
Supplemental Table 5 - Exclusion Criteria for Genotyping
Supplemental Table 6 - DDI Study Subject Disposition
Supplemental Table 7 - DDI Study Demographics and Baseline Characteristics
Supplemental Table 8 - Human DDI Study Pharmacokinetics Analyses - Summary Statistics
Supplemental Table 9 - Summary Statistics for INR AUC0-0168 and INRmax in the Warfarin DDI Study
Supplemental Table 10 - ANOVA Comparison of Geometric Least Square Means for INR AUC0-0168 and INRmax in the Warfarin DDI Study
Supplemental Figure 1 - Gastric pH Study Design Schematic
Supplemental Figure 2 - Drug-Drug Interaction Study Design (Furosemide, Aspirin, Warfarin)
Supplemental Figure 3 - Drug-Drug Interaction Study Design (Dabigatran)
Supplemental Figure 4 - Effect of Food: Water Administered under Fasting vs. Fed Conditions
Supplemental Figure 5 - Effect of Omeprazole: Water Administered under Fasting Conditions Without vs. With Omeprazole
Supplemental Figure 6 - Mean (SD) Plasma Furosemide Concentration Profile over Time (Linear Scale)
Supplemental Figure 7 - Mean Plasma Furosemide Concentration Profile over Time (Log-Linear Scale)
Supplemental Figure 8 - Mean (SD) Plasma Acetylsalicylic Acid Concentration Profile over Time (Linear Scale)
Supplemental Figure 9 - Mean Plasma Acetylsalicylic Acid Concentration Profile over Time (Log-Linear Scale)
Supplemental Figure 10 - Mean (SD) Plasma Salicylic Acid Concentration Profile over Time (Linear Scale)
Supplemental Figure 11 - Mean Plasma Salicylic Acid Concentration Profile over Time (Log-Linear Scale)
Supplemental Figure 12 - Mean (SD) Plasma R-Warfarin Concentration Profile over Time (Linear Scale)
Supplemental Figure 13 - Mean Plasma R-Warfarin Concentration Profile over Time (Log-Linear Scale)
Supplemental Figure 14 - Mean (SD) Plasma S-Warfarin Concentration Profile over Time (Linear Scale)
Supplemental Figure 15 - Mean Plasma S-Warfarin Concentration Profile over Time (Log-Linear Scale)
Supplemental Figure 16 - Mean (SD) Plasma Total Dabigatran Concentration Profile over Time (Linear Scale)
Supplemental Figure 17 - Mean Plasma Total Dabigatran Concentration Profile over Time (Log-Linear Scale)
Supplemental Figure 18 - Mean (SD) Plasma Free Dabigatran Concentration Profile over Time (Linear Scale)
Supplemental Figure 19 - Mean Plasma Free Dabigatran Concentration Profile over Time (Log-Linear Scale)
Supplemental Figure 20 - Mean (SD) International Normalized Ratio over Time (Linear Scale)
Supplemental Figure 21 - Mean International Normalized Ratio over Time (Log-Linear Scale)