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OtherArticle

Cytochrome P450 Binding and Bioactivation of Tumor-targeted Duocarmycin Agents

Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott
Drug Metabolism and Disposition October 4, 2021, DMD-AR-2021-000642; DOI: https://doi.org/10.1124/dmd.121.000642
Aaron G. Bart
1University of Michigan, United States
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Goreti Morais
2University of Bradford, United Kingdom
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Venu R. Vangala
2University of Bradford, United Kingdom
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Paul M. Loadman
3Institute of Cancer Therapeutics, University of Bradford, United Kingdom
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Klaus Pors
2University of Bradford, United Kingdom
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  • For correspondence: scottee@umich.edu
Emily E. Scott
4Dept of Medicinal Chemistry, University of Michigan, United States
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  • For correspondence: scottee@umich.edu

Data Supplement

  • Supplemental Data -


    Table S1. Crystallographic data for ICT2700 and ICT2726 small molecule structures.
    Table S2. LC-MS gradient method.
    Figure S1. Structures of ICT2700 and ICT2726 as determined by single molecule X-ray crystallography.


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