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OtherArticle

INTERSYSTEM EXTRAPOLATION FACTORS (ISEF) ARE SUBSTRATE-DEPENDENT FOR CYP3A4: IMPACT ON CYTOCHROME P450 REACTION PHENOTYPING

Alyssa L Dantonio, Angela C. Doran and R. Scott Obach
Drug Metabolism and Disposition December 13, 2021, DMD-AR-2021-000758; DOI: https://doi.org/10.1124/dmd.121.000758
Alyssa L Dantonio
1Pfizer, United States
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Angela C. Doran
2Medicine Design - ADME Sciences, Pfizer, United States
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R. Scott Obach
3Groton Laboratories, Pfizer Inc., United States
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  • For correspondence: r.scott.obach@pfizer.com

Data Supplement

  • Supplemental Tables -

    Supplemental Tables 1 and 2: Samples were analyzed using a liquid chromatography-tandem mass spectrometry (LCMS/MS) system

    SUPPLEMENTAL TABLE 3. Unbound fraction in microsomes.

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