Inter-individual variability and differential tissue abundance of mitochondrial amidoxime reducing component (mARC) in humans

Data Supplement

• Supplemental Data -

  Table S1: Optimized MS/MS parameters used for the quantification of mARC enzymes.

  Table S2: Demographic information of samples used in mARC enzymes quantification.

  Table S3: Chromatographic conditions for the separation of mARC1 and mARC2 surrogate peptides.

  Table S4: Analytical validation parameters of muLC MS/MS method used for quantitative analysis of mARC enzymes.

  Table S5: Protein recovery (mg of membrane or S9 protein per gram of tissue) in different organ and scaled abundance of mARC1 and mARC2 (pmol/gm tissue).

  Figure S1: mARC1 and mARC2 calibration curve in which digests of recombinant protein served as calibrators.

  Figure S2: Correlation of mARC1 and mARC2 abundance in paired liver and kidney samples...

  Figure S3: Correlation of mitochondrial marker (CH60) and mARC1 (A) and mARC2 (B) abundance in differential tissue...

  Figure S4: Relative abundance of mARC enzymes in CHIM samples isolated from duodenum, jejunum, and ileum sections of human intestine.